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Generalizability of Randomized Controlled Trials to Routine Clinical Care in Ulcerative Colitis.
Inflamm Bowel Dis
January 2025
Inflammatory Bowel Disease Unit, Division of Gastroenterology and Hepatology, Department of Medicine, University of Calgary, 5th Floor Cal Wenzel Precision Health Building, 3280 Hospital Drive NW, Calgary, AB T2N 4Z6, Canada.
Background: Historically, randomized controlled trials (RCTs) have been criticized for being poorly generalizable to patients with ulcerative colitis (UC) evaluated in routine care. We aimed to evaluate the proportion of patients with UC starting an advanced therapy who would be eligible to participate in phase 3 registrational UC RCTs.
Methods: We conducted a retrospective cohort analysis of UC patients starting vedolizumab, ustekinumab, or tofacitinib at 2 IBD clinics at the University of Calgary.
Alum sludge-driven electro-phytoremediation in constructed wetlands: a novel approach for sustainable nutrient removal.
RSC Adv
January 2025
Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences Tehran Iran
In addition to their advantages as promising methods for wastewater treatment, CWs exhibit poor performance in terms of N and P removal efficiency in the effluent of wastewater treatment plants. By focusing on this issue, we designed CWs integrated with a biochar-doped activated carbon cloth (ACC) electrode and alum sludge from water treatment plants as a substrate to achieve concomitant organic matter and nutrient removal efficiency. Compared with the use of one layer of alum sludge in CWs (CWs-C3) with ACC electrodes inserted in two layers, which uses one layer of alum sludge, a significant improvement in removal efficiency was achieved (96% for COD; 89% for TN; and 77% for TP).
View Article and Find Full Text PDFOncogenic competence: balancing mutations, cellular state, and microenvironment.
Trends Cancer
January 2025
Institute of Oncology Research (IOR), Bellinzona Institutes of Science (BIOS+), Bellinzona, Switzerland; Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland. Electronic address:
Cancer development is driven by mutations, yet tumor-causing mutations only lead to tumor formation within specific cellular contexts. The reasons why certain mutations trigger malignant transformation in some contexts but not others remain often unclear. Both intrinsic and extrinsic factors play a key role in driving carcinogenesis by leading the cells toward a state of 'oncogenic competence'.
View Article and Find Full Text PDFRational choices elicit stronger sense of agency in brain and behavior.
Cognition
January 2025
Chair of Philosophy of Mind, Faculty of Philosophy, Philosophy of Science and Religious Studies Ludwig-Maximilians-Universität München, Munich, Germany; Munich Center for Neuroscience, Ludwig-Maximilians-Universität München, Munich, Germany; Institute of Philosophy, School of Advanced Study, University of London, London, UK; Cognition, Values, Behaviour Lab, Ludwig-Maximilians-Universität München, Munich, Germany. Electronic address:
The sense of agency is the subjective feeling of control over one's own actions and the associated outcomes. Here, we asked whether and to what extent the reasons behind our choices (operationalized by value differences, expected utility, and counterfactual option sets) drive our sense of agency. We simultaneously tested these three dimensions during a novel value-based decision-making task while recording explicit (self-reported) and implicit (brain signals) measures of agency.
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