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Impact of Post-Thaw Enrichment of Primary Human Hepatocytes on Steatosis, Inflammation, and Fibrosis in the TruVivo System.
Pharmaceuticals (Basel)
December 2024
Institute of Regenerative Medicine, LifeNet Health, VA Beach, VA 23453, USA.
: Liver diseases are a global health concern. Many in vitro liver models utilize cryopreserved primary human hepatocytes (PHHs), which commonly undergo post-thaw processing through colloidal silica gradients to remove debris and enrich for a viable PHH population. Post-thaw processing effects on healthy PHHs are partially understood, but the consequences of applying disease-origin PHHs to post-thaw density gradient separation have not been described.
View Article and Find Full Text PDFEco-Friendly Synthesis of Quinazoline Derivatives Through Visible Light-Driven Photocatalysis Using Curcumin-Sensitized Titanium Dioxide.
Materials (Basel)
December 2024
Department of Chemistry, College of Science and Humanities in Al-Kharj, Prince Sattam Bin Abdulaziz University, P.O. Box 173, Al-Kharj 11942, Saudi Arabia.
This study explores a sustainable method for synthesizing quinazoline derivatives through visible light-driven photocatalysis using curcumin-sensitized titanium dioxide (TiO) nanoparticles. A one-pot, three-component reaction involving aldehydes, urea/thiourea, and dimedone was utilized to efficiently produce quinazoline compounds. The photocatalytic performance of curcumin-sensitized TiO (Cur-TiO) was compared to pure TiO (P-TiO), with Cur-TiO showing significantly enhanced activity.
View Article and Find Full Text PDFGalectin Plasmatic Levels Reveal a Cluster Associated with Disease Aggressiveness and Kidney Damage in Multiple Myeloma Patients.
Int J Mol Sci
December 2024
Research Center for Therapeutic Innovation (NUPIT-SG), Federal University of Pernambuco, Recife 50670-901, PE, Brazil.
Multiple myeloma (MM) is a malignant disease characterized by the proliferation of plasma cells, primarily in the bone marrow. It accounts for approximately 1% of all cancers and 10% of hematologic malignancies. Clinical manifestations include hypercalcemia, anemia, renal failure, and bone lesions.
View Article and Find Full Text PDFIntegrated Analysis of Transcriptome and Metabolome in the Brain After Cold Stress of Red Tilapia During Overwintering.
Int J Mol Sci
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Freshwater Fisheries Research Centre of Chinese Academy of Fishery Sciences, Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture and Rural Affairs, Wuxi 214081, China.
Cold stress during overwintering is considered a bottleneck problem limiting the development of the red tilapia ( spp.) industry, and the regulation mechanism is currently not well understood. In this study, the fish (initial weight: 72.
View Article and Find Full Text PDFEffects of Substitution of Wheat Straw by Giant Reed on Growth Performance, Serum Biochemical Parameters, Nutrient Digestibility, and Antioxidant Properties of Sheep.
Animals (Basel)
December 2024
State Engineering Technology Institute for Karst Desertfication Control, School of Karst Science, Guizhou Normal University, Guiyang 550025, China.
The development and utilization of unconventional forage resources is crucial to alleviating the current situation of shortage of forage resources. Giant reed () is a promising forage resource from the Poaceae family, one of the largest herbaceous plants globally, with fast growth, high biomass yield, and strong ecological adaptability. However, there are still very few reports on the use of giant reed in livestock and poultry production.
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