Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/NUR.0000000000000758 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Xylazine-Associated Necrotic Upper-Extremity Wounds: A Single Hospital System's Experience with 82 Patients and 125 Wounds.
J Bone Joint Surg Am
December 2024
Philadelphia Hand to Shoulder Center, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania.
Background: The rise in xylazine-adulterated heroin and fentanyl poses novel challenges to hand surgeons and a rising epidemic of necrotic upper-extremity wounds. While prior case studies have focused on particularly severe and complex xylazine-associated necrotic (XAN) wounds, the aim of this consecutive case series was to characterize the variability of presentations (ranging from mild to severe) at a single institution at the epicenter of the xylazine epidemic.
Methods: Patients presenting to a tertiary referral center for XAN upper-extremity wounds were retrospectively identified from emergency department visits and hospital admissions between January 2021 and December 2023.
Hyperspectral Raman imaging with multivariate curve resolution-alternating least square (MCR-ALS) analysis for xylazine-containing drug mixtures.
Forensic Sci Int
November 2024
School of Criminal Justice, Forensic Science, and Security, The University of Southern Mississippi, Hattiesburg, MS 39406, United States. Electronic address:
Xylazine, increasingly implicated in illicit opioid overdose deaths, poses a significant public health threat due to its synergistic effects with fentanyl and resistance to naloxone reversal. Despite its rising prevalence, xylazine is not classified as a controlled substance, leading to its exclusion from routine forensic screening. This study introduces a novel analytical method combining Raman hyperspectral imaging with Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS) to detect xylazine in drug mixtures containing common excipients such as acetaminophen, dipyrone, and mannitol.
View Article and Find Full Text PDFPreventing Substance Use and Overdose Among Young Adults: The Role of Social Determinants of Health.
Focus (Am Psychiatr Publ)
October 2024
Center for Substance Abuse Prevention, Substance Abuse and Mental Health Services Administration, Rockville, Maryland.
The United States is in the midst of an evolving overdose crisis, driven by the proliferation of potent synthetic opioids (e.g., illicitly made fentanyl), the resurgence of stimulants (e.
View Article and Find Full Text PDFIncreasing Prevalence of Xylazine and Worsening Upper-Extremity Wounds in Injection Drug Use: A Local Phenomenon With National Implications.
J Hand Surg Am
November 2024
Division of Plastic Surgery, Department of Surgery, Penn Medicine, Philadelphia, PA; Department of Orthopaedic Surgery, Penn Medicine, Philadelphia, PA. Electronic address:
The rising presence of xylazine in Philadelphia's fentanyl supply has led to various upper-extremity complications in individuals who inject drugs. Sociogeographic trends predict that our current local phenomenon will spread nationally. We aim to discuss the drug's impact on clinical presentation and patient care via a cohort of five patients with upper-extremity wounds related to drug use.
View Article and Find Full Text PDFOpioid-related xylazine toxicity manifesting as myonecrosis, rhabdomyolysis, multifocal ischemic cerebral infarcts, and cerebral edema.
J Am Coll Emerg Physicians Open
June 2024
Division of Pulmonary, Allergy, and Critical Care University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania USA.
This article provides a report of a case of organ dysfunction, myonecrosis, rhabdomyolysis, multifocal ischemic cerebral infarcts, and cerebral edema after a patient's use of xylazine and fentanyl. Within the US opioid epidemic, xylazine is emerging as a troubling national sub-story. The prevalence of xylazine within illicitly manufactured opioids and the proportion of opioid-involved overdose deaths with detected xylazine are rising dramatically, the latter increasing 276% between 2019 and 2022.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!