Trends in the Analysis and Exploration of per- and Polyfluoroalkyl Substances (PFAS) in Environmental Matrices: A Review.

Per- and polyfluoroalkyl substances (PFAS) is an emerging class of organic pollutants of concern and is now prevalent in environmental matrices including water, soil, air, and biological. So far, several standard analytical methods have been developed to systematically analyze PFAS in different environmental matrices. However, the complexity of environmental matrices makes the effective extraction of PFAS difficult, and the legacy PFAS is gradually changing into a new PFAS with short chain and unknown structure in production, which makes the analysis of PFAS challenging. In this review, the following aspects are summarized: (1) the advances in standard analytical methods for PFAS in different environmental matrices, and further generalizes the updating novel extraction and detection methods; (2) the analysis of unknown PFAS, the suspect and non-targeted screening analysis method of PFAS based on high-resolution mass spectrometry (HRMS) is systematically described.