AI Article Synopsis
- Esophageal cancer often has a poor prognosis, and the common one-line treatment for metastatic cases is a combination of chemotherapy that includes platinum and 5-fluorouracil (5-FU).
- A 74-year-old man with metastatic esophageal cancer was discovered to have a partial deficiency in the enzyme dihydropyrimidine dehydrogenase (DPD), which can increase the risk of severe side effects from 5-FU treatment.
- The safe administration of 5-FU to the patient was made possible through therapeutic drug monitoring (TDM), emphasizing the significance of individualized dosing to minimize toxicities in patients with partial DPD deficiency.
Article Abstract
Esophageal cancer is a cancer with poor prognosis and the standard 1 line treatment for metastatic or recurrent EC is systemic chemotherapy with doublet chemotherapy based on platinum and 5-fluorouracil (5-FU). However, 5-FU could be a source of severe treatment-related toxicities due to deficiency of dihydropyrimidine dehydrogenase (DPD). In this case report, a 74-year-old man with metastatic esophageal cancer was found to have partial DPD deficiency based on uracilemia measurements (about 90 ng/mL). Despite this, 5-FU was safely administered thanks to therapeutic drug monitoring (TDM). The case report highlights the importance of TDM in administering 5-FU to patients with partial DPD deficiency, as it allows individualized dosing and prevents severe toxicity.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319454 | PMC |
| http://dx.doi.org/10.3389/fonc.2023.1187052 | DOI Listing |
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