Cetaceans have shown a potential to be used as sentinel species for tracking environmental change in marine ecosystems, yet our assessment of change is typically limited to recent decades and lacks ecological baselines. Using historical museum specimens, we compared community niche metrics and degree of individual dietary specialization in groups of Pacific Arctic beluga () from the 1800s ( = 5) to 1900s ( = 10) using stable carbon and nitrogen isotopes drilled from teeth. Beluga occupied a broader trophic niche and demonstrated a higher degree of individual specialization in the 1800s than in the 1900s. The cause of this shift is difficult to confirm given long timescales and constraints of specimen-based research but could indicate changes in the prey base or competition. The scale and nature of this detected shift provide perspective for continued research on these climate-vulnerable species.
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http://dx.doi.org/10.1002/ece3.10230 | DOI Listing |
Diabetes
December 2024
Epigenetics and Diabetes Unit, Department of Clinical Sciences Malmö, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden.
There is an increasing need for new biomarkers improving prediction of chronic kidney disease (CKD) in individuals with type 2 diabetes (T2D). We aimed to identify blood-based epigenetic biomarkers associated with incident CKD and develop a methylation risk score (MRS) predicting CKD in newlydiagnosed individuals with T2D. DNA methylation was analysed epigenome-wide in blood from 487 newly-diagnosed individuals with T2D, of whom 88 developed CKD during 11.
View Article and Find Full Text PDFJMIR Form Res
December 2024
Division of Drug Informatics, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo, Japan.
Background: Medication compliance, which refers to the extent to which patients correctly adhere to prescribed regimens, is influenced by various psychological, behavioral, and demographic factors. When analyzing these factors, challenges such as multicollinearity and variable selection often arise, complicating the interpretation of results. To address the issue of multicollinearity and better analyze the importance of each factor, machine learning methods are considered to be useful.
View Article and Find Full Text PDFJMIR Res Protoc
December 2024
Department of Community Medicine, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Karnataka, Manipal, 576 104, India.
Background: Differentiating between tuberculosis and malignancy as the cause of an exudative lymphocyte predominant pleural effusion is difficult due to similarities in the cellular and biochemical characteristics of the pleural fluid in both conditions. Microbiological tests in tubercular pleural effusions have a poor diagnostic yield, and the long turnaround time for results prevents an early diagnosis. The diagnosis of malignant pleural effusion (MPE) is hampered by a variable yield of pleural fluid cytology and closed pleural biopsy and the fact that thoracoscopy may not be readily available or feasible in each patient.
View Article and Find Full Text PDFJMIR Form Res
December 2024
Autism and Developmental Medicine Institute, Geisinger, Lewisburg, PA, United States.
Background: Medical marijuana (MMJ) is available in Pennsylvania, and participation in the state-regulated program requires patient registration and receiving certification by an approved physician. Currently, no integration of MMJ certification data with health records exists in Pennsylvania that would allow clinicians to rapidly identify patients using MMJ, as exists with other scheduled drugs. This absence of a formal data sharing structure necessitates tools aiding in consistent documentation practices to enable comprehensive patient care.
View Article and Find Full Text PDFJ Craniofac Surg
December 2024
Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry, Seodaemun-gu.
Glabellar filler injections are a popular non-surgical approach to address depressions and wrinkles caused by aging, muscle activity, and soft tissue loss. An anatomy-based technique emphasizes understanding the complex structure of the glabellar region, including the corrugator supercilii and procerus muscles, and the superficial vascular pathways, such as the supratrochlear and supraorbital arteries. Effective treatment involves precise filler placement, often combined with botulinum toxin to address both volume loss and dynamic wrinkles.
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