AI Article Synopsis
- Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has significantly improved survival rates for patients with blood cancers, but disease relapse remains a major challenge.
- Pre-emptive treatments based on measurable residual disease and maintenance therapies are showing promise in reducing relapse rates, especially for high-risk patients.
- New novel agents and cellular therapies are being developed to enhance antitumor activity while minimizing toxicity, offering new potential strategies for post-transplant care, particularly for acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).
Article Abstract
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has improved survival for patients with hematological malignancy, especially for those highly at risk of relapse. However, disease relapse after allo-HSCT remains the most common cause of treatment failure and death, even with conventional chemotherapy and donor lymphocyte infusion. Disease relapse in allo-HSCT can be reduced via pre-emptive treatment based on measurable residual disease and maintenance therapy for patients at high risk of relapse as promising treatment strategies. Recently, the development of novel agents and cellular therapies with high antitumor activity and less toxicity, which can be used in the post-transplant setting, has increased their clinical applications in the therapeutic approach. This review examines the current landscape and future strategies for maintenance therapy, mainly for AML and ALL after allo-HSCT.
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| http://dx.doi.org/10.11406/rinketsu.64.533 | DOI Listing |
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