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Targeting the metabolism and immune system in pancreatic ductal adenocarcinoma: Insights and future directions. | LitMetric

Targeting the metabolism and immune system in pancreatic ductal adenocarcinoma: Insights and future directions.

Cytokine Growth Factor Rev

Department of Hematology and Oncology, Heersink School of Medicine, University of Alabama, Birmingham, AL 35233, USA. Electronic address:

Published: November 2023

AI Article Synopsis

  • * Key factors like genetic changes, lysosomal issues, gut microbiome imbalances, and altered metabolic pathways affect immunometabolism in PDAC, impacting immune cell functions and evading anti-tumor responses.
  • * Ongoing advancements in immunotherapy show promise for overcoming the challenges posed by the immunosuppressive TME, with research focusing on the interplay between immunometabolism, genetics, and microbiome to enhance treatment outcomes for PDAC patients.

Article Abstract

Pancreatic cancer, specifically pancreatic ductal adenocarcinoma (PDAC), presents a challenging landscape due to its complex nature and the highly immunosuppressive tumor microenvironment (TME). This immunosuppression severely limits the effectiveness of immune-based therapies. Studies have revealed the critical role of immunometabolism in shaping the TME and influencing PDAC progression. Genetic alterations, lysosomal dysfunction, gut microbiome dysbiosis, and altered metabolic pathways have been shown to modulate immunometabolism in PDAC. These metabolic alterations can significantly impact immune cell functions, including T-cells, myeloid-derived suppressor cells (MDSCs), and macrophages, evading anti-tumor immunity. Advances in immunotherapy offer promising avenues for overcoming immunosuppressive TME and enhancing patient outcomes. This review highlights the challenges and opportunities for future research in this evolving field. By exploring the connections between immunometabolism, genetic alterations, and the microbiome in PDAC, it is possible to tailor novel approaches capable of improving immunotherapy outcomes and addressing the limitations posed by immunosuppressive TME. Ultimately, these insights may pave the way for improved treatment options and better outcomes for PDAC patients.

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Source
http://dx.doi.org/10.1016/j.cytogfr.2023.06.006DOI Listing

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