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Single-Cell RNA Sequencing of PBMCs Identified Junction Plakoglobin (JUP) as Stratification Biomarker for Endometriosis.
Int J Mol Sci
December 2024
Endometriosis & Gynaecological Oncology Laboratory (EndoGO), Department for Biomedical Research (DBMR), University of Bern, Murtenstrasse 35, 3008 Bern, Switzerland.
This study aimed to identify unique characteristics in the peripheral blood mononuclear cells (PBMCs) of endometriosis patients and develop a non-invasive early diagnostic tool. Using single-cell RNA sequencing (scRNA-seq), we constructed the first single-cell atlas of PBMCs from endometriosis patients based on 107,964 cells and 25,847 genes. Within CD16 monocytes, we discovered as a dysregulated gene.
View Article and Find Full Text PDFExcess shed mesothelin disrupts pancreatic cancer cell clustering to impair peritoneal colonization.
FASEB J
December 2024
Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Peritoneum is the second most common site of metastasis in patients with pancreatic ductal adenocarcinoma (PDAC). Peritoneal colonization is impaired in PDAC cells with knockout (KO) of the cancer surface antigen mesothelin (MSLN) or by introducing Y318A mutation in MSLN to prevent binding to mucin-16 (MUC-16). MSLN has a membrane-bound form but is also shed to release soluble MSLN (sMSLN).
View Article and Find Full Text PDFEffect of endometriosis on prognosis of ovarian clear cell carcinoma: a 10-year retrospective study.
Front Oncol
November 2024
Department of Gynecological Oncology, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Article Synopsis
- The study investigates the role of endometriosis as a prognostic factor in ovarian clear cell carcinoma (OCCC) patients and examines the effects of other clinical features on patient outcomes.
- A retrospective analysis of 105 OCCC patients, categorized based on the presence of endometriosis, found no significant differences in overall survival (OS) or progression-free survival (PFS) between the two groups.
- Key factors influencing recurrence and survival included residual tumors, staging, site invasion, and chemotherapy efficacy, but endometriosis itself did not significantly impact prognosis.
Clear Cell Carcinoma Arising From Adenomyotic Cyst: A Case Report.
Cureus
October 2024
Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JPN.
Article Synopsis
- - A 38-year-old woman with a uterine tumor was diagnosed with clear cell carcinoma arising from an adenomyotic cyst, after imaging and elevated tumor markers indicated potential malignancy.
- - Initial surgery aimed at preserving her fertility involved a myomectomy, but further examinations confirmed clear cell carcinoma and a subsequent hysterectomy and other procedures revealed metastasis to lymph nodes.
- - The patient was treated with chemotherapy and immunotherapy, but 18 months later showed signs of treatment resistance with new liver and lymph node metastases.
Giant serous cystadenoma in an adolescent: A case report.
SAGE Open Med Case Rep
October 2024
Centre Hospitalier Universitaire Mohammed VI, Oujda, Morocco.
Article Synopsis
- - Ovarian tumors in children are rare, occurring at a rate of 2.6 per 100,000, with symptoms often including abdominal pain and the need for thorough diagnostic evaluation using imaging like pelvic ultrasounds.
- - A 15-year-old girl presented with a six-month history of an enlarging abdominal mass and negative tumor markers, leading to an ultrasound and MRI that revealed a large cystic mass occupying her abdomen and pelvis.
- - She underwent laparoscopic surgery to remove the cyst, which involved draining 6 liters of fluid and preserving part of her left ovary; follow-up care is ongoing.
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