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Severe caffeine poisoning with mexiletine successfully treated by extracorporeal methods.
Am J Emerg Med
December 2024
Department of Critical Care Medicine and Trauma, National Hospital Organization Disaster Medical Center, Japan.
Article Synopsis
- A 20-year-old woman was hospitalized after consuming high doses of caffeine (18g) and mexiletine (3500mg), leading to severe hypotension, tachycardia, hypokalemia, and lactic acidosis.
- She underwent multiple medical interventions, including mechanical ventilation, noradrenaline infusion, and hemodialysis (HD), as her condition worsened to pulseless ventricular tachycardia requiring VA-ECMO support.
- The case highlighted that mexiletine may hinder caffeine clearance, complicating treatment; however, after HD, her drug levels decreased significantly, allowing successful recovery and weaning from life support within a few days.
Psychosis following caffeine consumption in a young adolescent: Review of case and literature.
Ann Afr Med
July 2023
Department of Paediatrics, Alliance Hospital, Abuja, Nigeria.
Caffeine, a popular over-the-counter methylxanthine, is widely consumed for its potent psychoactive properties. Toxicity generally occurs with intentional overdose and is often multisystemic and life-threatening. Consumption by children is rarely planned, and safe doses are potentially toxic in them.
View Article and Find Full Text PDFA case of refractory ventricular fibrillation after caffeine poisoning successfully treated by supportive care.
Toxicol Rep
August 2022
Department of Emergency Medicine, Seoul Metropolitan Government Seoul National University, Boramae Medical Center, Republic of Korea.
Caffeine (1,3,7-trimethylxantine), a structural analog of adenosine, is widely used as a central nervous system stimulant in beverages and drugs. Caffeine overdose induces hypokalemia, fatal ventricular fibrillation, and cardiac arrest, resulting in death. We describe a case of caffeine overdose that presented with refractory ventricular fibrillation that was treated with supportive care because invasive care for severely ill patients was limited due to the COVID-19 pandemic.
View Article and Find Full Text PDFPharmacokinetic Interactions of a Licorice Dietary Supplement with Cytochrome P450 Enzymes in Female Participants.
Drug Metab Dispos
February 2023
Linus Pauling Institute, College of Pharmacy, Oregon State University, Corvallis, Oregon (J.L., R.B.v.B.) and UIC Center for Botanical Dietary Supplements Research, Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois (S.B., M.V., E.B., S.-N.C., G.F.P., R.B.v.B.)
Licorice, the roots and rhizomes of L., has been used as a medicinal herb, herbal adjuvant, and flavoring agent since ancient times. Recently, licorice extracts have become popular as dietary supplements used by females to alleviate menopausal symptoms.
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