Specialist industries usually develop custom-made medical devices outside a medical structure at the request of a healthcare professional. Access to 3D-printing technology with dedicated softwares in hospitals allow surgeons to perform virtual surgery leading to safer and more precise surgery. The authors present the hybrid workflow that combined the skills of surgeons, engineers and manufacturers to create titanium custom-made cutting guide and implants to reconstruct the nasal bone after the resection of an intraosseous hemangioma. This process aimed to optimize pre-operative planning, to improve precision, to predict the esthetic results of reconstruction. Moreover, it leads to a reduction of manufacturing time and the overall costs of surgery and to achieve genuine custom-made care.
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http://dx.doi.org/10.1016/j.jormas.2023.101548 | DOI Listing |
Alzheimers Dement
December 2024
University of Connecticut School of Medicine, Farmington, CT, USA.
Background: This presentation maps the journey of an evidence-based dementia care program from effectiveness trial design to adoption by policymakers as an ongoing program available to eligible older adults living at home with dementia and their care partners. Care of People with Dementia in their Environments (COPE) is a non-pharmacologic program that seeks to maximize physical function and quality of life in people with dementia and build dementia management skills in care partners. Efficacy trial results showed that, compared to controls, people with dementia receiving COPE had greater functional independence in activities of daily living and care partners receiving COPE reported improved well-being and increased confidence using dementia management skills.
View Article and Find Full Text PDFSci Rep
January 2025
Hubbard Center for Genome Studies, University of New Hampshire, Durham, NH, 03824, USA.
Environmental DNA (eDNA) is revolutionizing how we investigate biodiversity in aquatic and terrestrial environments. It is increasingly used for detecting rare and invasive species, assessing biodiversity loss and monitoring fish communities, as it is considered a cost-effective and noninvasive approach. Some environments, however, can be challenging for eDNA analyses.
View Article and Find Full Text PDFBackground: Ambient artificial intelligence offers promise for improving documentation efficiency and reducing provider burden through clinical note generation. However, challenges persist in workflow integration, compliance, and widespread adoption. This study leveraged a Learning Health System (LHS) framework to align research and operations using a hybrid effectiveness-implementation protocol, embedded as pragmatic trial operations within the electronic health record (EHR).
View Article and Find Full Text PDFACS Nano
January 2025
South China Advanced Institute for Soft Matter Science and Technology, School of Emergent Soft Matter, South China University of Technology, Guangzhou 510640, China.
Synthetic single-wall carbon nanotubes (SWCNTs) contain various chiralities, which can be sorted by DNA. However, finding DNA sequences for this purpose mainly relies on trial-and-error methods. Predicting the right DNA sequences to sort SWCNTs remains a substantial challenge.
View Article and Find Full Text PDFJ Med Chem
January 2025
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
The tedious synthesis and limited throughput biological evaluation remain a great challenge for discovering new proteolysis targeting chimera (PROTAC). To rapidly identify potential PROTAC lead compounds, we report a platform named Auto-RapTAC. Based on the modular characteristic of the PROTAC molecule, a streamlined workflow that integrates lab automation with "click chemistry" joint building-block libraries was constructed.
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