A facile one-pot metal-free, base-mediated formal [3 + 2] and [4 + 2] dearomative -cycloaddition of -quinone methides (-QMs) with halo alcohols has been designed for the efficient construction of 2-oxa-spirocyclohexadienones in excellent yield under mild reaction conditions. The commercial availability of the bases, reagents, and convenient reaction procedure makes it an attractive method for -cyclization.
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| http://dx.doi.org/10.1021/acs.joc.3c00784 | DOI Listing |
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