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Home math environment as a mediator of socioeconomic differences in early math skills: A study of Chinese families from disparate backgrounds.
Dev Psychol
January 2025
Lynch School of Education and Human Development, Boston College.
Children exhibit substantial variation in their early math skills, with pronounced achievement gaps by socioeconomic status (SES) observable even before formal schooling. These SES-related differences in math skills are long-standing and globally observed, prompting investigations into how SES variations in home math environment contribute to early math development. The present study employed a mixed-methods design to examine the relations among SES, key aspects of home math environment, and early math skills in a non-Western context.
View Article and Find Full Text PDFOpportunities for More Tailored Approaches to Genotoxicity Testing and Carcinogenicity Strategy for Oligonucleotide Therapeutics: Outcome of an Industry Survey.
Nucleic Acid Ther
January 2025
Global Preclinical Safety, AbbVie Inc., North Chicago, Illinois, USA.
The Oligonucleotide Nonclinical Working Group (WG) of the European Federation of Pharmaceutical Industries and Associations conducted an industry survey to understand current practices and regulatory expectations for genotoxicity and carcinogenicity assessment of oligonucleotide therapeutics (ONTs), along with historical genotoxicity testing results. The survey, involving 29 pharmaceutical and biotechnology companies, revealed a consistent absence of genotoxicity across a diverse range of oligonucleotide classes and chemistries, consistent with previous observations. Despite the lack of genotoxicity, companies continue to follow standard testing guidelines, with only limited divergence.
View Article and Find Full Text PDFDehydration-induced regulates midgut infection in mosquitoes.
mBio
January 2025
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Unlabelled: Climate change is predicted to increase the spread of mosquito-borne viruses, but genetic mechanisms underlying the influence of environmental variation on the ability of insect vectors to transmit human pathogens is unknown. In response to a changing climate, mosquitoes will experience longer periods of drought. An important physiological response to dry environments is the protection against dehydration, here defined as desiccation tolerance.
View Article and Find Full Text PDFThe use of coaching in stroke rehabilitation: a scoping review.
Disabil Rehabil
January 2025
School of Rehabilitation Therapy, Queen's University, Kingston, Canada.
Purpose: Stroke results in long-term impacts on a person's life requiring ongoing management after formal rehabilitation ends. Coaching can support people to build competencies and skills for managing health-related challenges and has the potential to support stroke survivors to continue achieving goals on their own following rehabilitation. This review sought to describe the research on coaching interventions for adults living with stroke.
View Article and Find Full Text PDFAlternative driver pathways in peripheral nerve sheath tumors - including DICER1 and/or KRAS alterations.
J Pathol
January 2025
Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
DICER1-associated sarcoma is an emerging entity, defined by either somatic or germline dicer 1, ribonuclease III (DICER1) mutations and sharing characteristic morphologic features irrespective of the site of origin. In addition to the DICER1 driver mutation, concurrent genomic alterations, including tumor protein 53 (TP53) inactivation and RAS pathway activation, are frequently detected. Tumors that morphologically resemble malignant peripheral nerve sheath tumor (MPNST) have rarely been reported among DICER1 sarcomas and often pose diagnostic challenges.
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