After rotavirus was discovered in 1973, it became the leading pathogen in causing acute gastroenteritis in humans worldwide. In this study, we performed whole genome sequencing and genomic characterization of a DS-1-like G2P[4] group A rotavirus in feces of a Japanese child with acute gastroenteritis who was fully Rotarix® vaccinated. The genomic investigation determined a genomic constellation G2-P[4]-I2-R2-C2-M2-A2-N2-T2-E2-H2 of this rotavirus strain. Its antigenic epitopes of the VP7 and VP4 proteins had significant mismatches compared with the vaccine strains. Our study is the latest attempt to investigate the evolution of the VP7 and VP4 genes of emerging G2P[4] rotavirus in Japan.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s11262-023-02018-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Global Protein Interactome Mapping in Rice Using Barcode-Indexed PCR Coupled with HiFi Long-Read Sequencing.
Adv Sci (Weinh)
January 2025
State Key Lab of Rice Biology and Breeding, China National Rice Research Institute, Hangzhou, 311400, China.
Establishing the protein-protein interaction network sheds light on functional genomics studies by providing insights from known counterparts. However, the rice interactome has barely been studied due to the lack of massive, reliable, and cost-effective methodologies. Here, the development of a barcode-indexed PCR coupled with HiFi long-read sequencing pipeline (BIP-seq) is reported for high throughput Protein Protein Interaction (PPI)identification.
View Article and Find Full Text PDFDetection of clinically relevant variants in the gene below 10% allelic frequency: A multicenter study by ERIC, the European Research Initiative on CLL.
Hemasphere
January 2025
Department of Internal Medicine, Hematology and Oncology, and Institute of Medical Genetics and Genomics, University Hospital Brno and Medical Faculty Masaryk University Brno Czech Republic.
In chronic lymphocytic leukemia, the reliability of next-generation sequencing (NGS) to detect variants ≤10% allelic frequency (low-VAF) is debated. We tested the ability to detect 23 such variants in 41 different laboratories using their NGS method of choice. The sensitivity was 85.
View Article and Find Full Text PDFKnockout of caused significant sinapine reduction in transgene-free rapeseed mutants generated by protoplast-based CRISPR RNP editing.
Front Plant Sci
January 2025
Department of Plant Breeding, Swedish University of Agricultural Sciences, Lomma, Sweden.
Rapeseed ( L.) is known for its high-quality seed oil and protein content. However, its use in animal feed is restricted due to antinutritional factors present in the seedcake, with sinapine being one of the main compounds that reduces palatability.
View Article and Find Full Text PDFIdentification of 39 stripe rust resistance loci in a panel of 465 winter wheat entries presumed to have high-temperature adult-plant resistance through genome-wide association mapping and marker-assisted detection.
Front Plant Sci
January 2025
Department of Plant Pathology, Washington State University, Pullman, WA, United States.
Stripe rust of wheat is a serious disease caused by f. sp. ().
View Article and Find Full Text PDFThe complete mitochondrial genome sequence of (Littorinimorpha: Truncatelloidea: Assimineidae).
Mitochondrial DNA B Resour
January 2025
East China Sea Ecological Center of the Ministry of Natural Resources, MNR, Shanghai, China.
In this study, the complete mitochondrial genome of was sequenced by Illumina high-throughput sequencing and its characteristics were analyzed. The mitogenome of is 16,635 bp long, and it encodes the standard set of 13 PCGs, 22 tRNA genes, and two rRNA genes. The mitogenome has a GC content of 29.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!