AI Article Synopsis
- Influenza A(H3N8) viruses were first found in people in 2022, but scientists haven't figured out how risky they are for public health yet.
- They studied H3N8 viruses from both birds and humans and found that human ones can attach to different types of cells, while bird ones can only stick to bird cells.
- H3N8 viruses can be treated with a medicine called oseltamivir, but because people haven't been exposed to these viruses before, they could still be dangerous, so we need to keep an eye on them.
Article Abstract
Influenza A(H3N8) viruses first emerged in humans in 2022, but their public health risk has not been evaluated. Here, we systematically investigated the biological features of avian and human isolated H3N8 viruses. The human-origin H3N8 viruses exhibited dual receptor binding profiles but avian-origin H3N8 viruses bound to avian type (sialic acid α2, 3) receptors only. All H3N8 viruses were sensitive to the antiviral drug oseltamivir. Although H3N8 viruses showed lower virulence than the 2009 pandemic H1N1 (09pdmH1N1) viruses, they induced comparable infectivity in mice. More importantly, the human population is naïve to H3N8 virus infection and current seasonal vaccination is not protective. Therefore, the threat of influenza A(H3N8) viruses should not be underestimated. Any variations should be monitored closely and their effect should be studied in time for the pandemic potential preparedness purpose.
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| http://dx.doi.org/10.1002/jmv.28912 | DOI Listing |
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- The research underscores the importance of understanding genetic diversity in influenza A viruses in polar regions to inform strategies against potential biological threats.*
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