Nanosensors are nanoscale devices that measure physical attributes and convert these signals into analyzable information. In preparation, for the impending reality of nanosensors in clinical practice, we confront important questions regarding the evidence supporting widespread device use. Our objectives are to demonstrate the value and implications for new nanosensors as they relate to the next phase of remote patient monitoring and to apply lessons learned from digital health devices through real-world examples.
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http://dx.doi.org/10.2217/pme-2022-0065 | DOI Listing |
J Fluoresc
January 2025
College of Biological and Chemical Engineering, Qilu Institute of Technology, Jinan, 250200, P.R. China.
Fluorescent carbon quantum dots (CDs) have received widespread attention for their potential applications in optical sensing. Meanwhile, as the importance of mercury ion (Hg) detection in the environment, the exploration of Hg fluorescent nanosensor based on CDs with high quantum yield is particularly intriguing. Herein, nitrogen-doped carbon quantum dots (N-CDs) were prepared by microwave method using citric acid as carbon source and urea as nitrogen source, and glycerol as microwave solvent.
View Article and Find Full Text PDFMikrochim Acta
January 2025
Department of Physics, Punjab Engineering College (Deemed to be University), Chandigarh, 160012, India.
Rapid and accurate detection of Escherichia coli (E. coli) is critical for maintaining water quality, and protecting aquatic ecosystems and public health. This research focuses on the development of a Förster resonance energy transfer (FRET)-based "turn-on" fluorescent nanosensor for real time, sensitive detection of E.
View Article and Find Full Text PDFSmall
January 2025
Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, No. 174 Shazheng Road, Chongqing, 400044, China.
Direct electrochemical detection of miRNA biomarkers in tumor tissue interstitial fluid (TIF) holds great promise for adjuvant therapy for tumors in the perioperative period, yet is limited by background interference and weak signal. Herein, a wash-free and separation-free miRNA biosensor based on photoexcited electro-driven reactive oxygen channeling analysis (LEOCA) is developed to solve the high-fidelity detection in physiological samples. In the presence of miRNA, nanoacceptors (ultrasmall-size polydopamine, uPDA) are responsively assembled on the surface of nanodonors (zirconium metal-organic framework, ZrMOF) to form core-satellite aggregates.
View Article and Find Full Text PDFAdv Mater
January 2025
Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, 610064, China.
Breast cancer (BC) is the second most common cause of cancer induced death worldwide. Current statistics has disclosed that the diabetic BC patients have significantly worse survival rate compared with nondiabetic BC patients. However, the specific mechanism is still being explored.
View Article and Find Full Text PDFNat Nanotechnol
January 2025
Wallace H. Coulter Department of Biomedical Engineering, Georgia Tech College of Engineering and Emory School of Medicine, Atlanta, GA, USA.
The forward design of biosensors that implement Boolean logic to improve detection precision primarily relies on programming genetic components to control transcriptional responses. However, cell- and gene-free nanomaterials programmed with logical functions may present lower barriers for clinical translation. Here we report the design of activity-based nanosensors that implement AND-gate logic without genetic parts via bi-labile cyclic peptides.
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