AI Article Synopsis
- Enterocyte uptake of oral nanocarriers poses challenges due to high binding efficiency and interference, but a new type of nanoparticle (SDPN) has been developed to address these issues by mimicking cell membranes.
- The SDPN nanoparticles show better stability in the gastrointestinal tract and improved uptake in cells, facilitating the delivery of cancer-fighting compounds like luteolin and silibinin to reduce breast cancer metastasis in mice.
- This innovative membrane-biomimetic approach not only enhances drug delivery effectiveness but also helps regulate immune responses and reduce cancer-related blood vessel growth, indicating its potential for future cancer therapies.
Article Abstract
Enterocyte uptake with high binding efficiency and minor endogenous interference remains a challenge in oral nanocarrier delivery. Enterocyte membrane-biomimetic lipids may universally cooperate with endogenous phosphatidyl choline via a biorthogonal group. In this study, we developed a sophorolipid-associated membrane-biomimetic choline phosphate-poly(lactic-co-glycolic) acid hybrid nanoparticle (SDPN). Aided by physical stability in the gastrointestinal tract and rapid mucus diffusion provided by association with sophorolipid, these nanoparticles show improved endocytosis, driven by dipalmitoyl choline phosphate-phosphatidyl choline interaction as well as its optimized membrane fluidity and rigidity. Luteolin- and silibinin-co-loaded with SDPN alleviated breast cancer metastasis in 4T1 tumor-bearing mice by regulating the conversion of tumor-associated M2 macrophages into the M1 phenotype and reducing the proportion of the M2-phenotype through co-action on STAT3 and HIF-1α. In addition, SDPN reduces angiogenesis and regulates the matrix barrier in the tumor microenvironment. In conclusion, this membrane-biomimetic strategy is promising for improving the enterocyte uptake of oral SDPN and shows potential to alleviate breast cancer metastasis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318786 | PMC |
| http://dx.doi.org/10.1186/s12951-023-01949-5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Milk osteopontin has high iron-binding capacity and facilitates iron absorption in intestinal cells.
J Dairy Sci
January 2025
Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark. Electronic address:
Insufficient absorption of iron and the consequent development of iron deficiency have serious health consequences. Hence, identification and development of iron delivery systems that can increase the bioavailability and uptake of dietary iron are important. Osteopontin (OPN) is an acidic and highly phosphorylated integrin-binding protein found in milk where it exists as a full-length protein and as N-terminally derived fragments.
View Article and Find Full Text PDFRegulation of lipid storage and inflammation in the liver by CEACAM1.
Eur J Clin Invest
December 2024
Department of Immunology and Theranostics, Arthur D. Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, California, USA.
This review focuses on a special aspect of hepatic lipid storage and inflammation that occurs during nutritional excess in obesity. Mounting evidence supports that prolonged excess fatty acid (FA) uptake in the liver is strongly associated with hepatic lipid storage and inflammation and that the two processes are closely linked by a homeostatic mechanism. There is also strong evidence that bacterial lipids may enter the gut by a common mechanism with lipid absorption and that there is a set point to determine when their uptake triggers an inflammatory response in the liver.
View Article and Find Full Text PDFMarked microcytosis and increased transferrin saturation: Think about variants in SLC11A2 (DMT1).
Blood Cells Mol Dis
February 2025
Service d'hémato-oncologie pédiatrique, Hôpital l'Archet, Nice, France.
Congenital microcytic anemias are rare diseases associated with decreased hemoglobin synthesis and red blood cells of low corpuscular volume. DMT1/NRAMP2 is a highly conserved divalent cation transporter encoded by the SLC11A2 gene, expressed at the membrane of various cells. It ensures ferrous iron absorption from the apical membrane of enterocytes, iron recovery from urine by renal tubules, and acidified endosome uptake after transferrin internalization.
View Article and Find Full Text PDFHow active cholesterol coordinates cell cholesterol homeostasis: Test of a hypothesis.
Prog Lipid Res
November 2024
Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, United States of America.
How do cells coordinate the diverse elements that regulate their cholesterol homeostasis? Our model postulates that membrane cholesterol forms simple complexes with bilayer phospholipids. The phospholipids in the plasma membrane are of high affinity; consequently, they are fully complexed with the sterol. This sets the resting level of plasma membrane cholesterol.
View Article and Find Full Text PDFPFOA/PFOS Facilitated Intestinal Fatty Acid Absorption by Activating the PPARα Pathway: Insights from Organoids Model.
Environ Health (Wash)
February 2024
Information Materials and Intelligent Sensing Laboratory of Anhui Province, Institutes of Physical Science and Information Technology, Anhui University, Hefei, Anhui 230601, China.
Perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS) continue to be extensively present in the natural environment and seriously threaten human health. The intestinal tract is the primary organ of PFOA/PFOS exposure due to the consumption of contaminated food and drinking water. However, it remains unclear how PFOA/PFOS affects intestinal function and overall health.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!