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Exploring the anti-aging potential of natural products and plant extracts in budding yeast : A review.
F1000Res
January 2025
Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.
Historically, plant derived natural products and their crude extracts have been used to treat a wide range of ailments across the world. Biogerontology research aims to explore the molecular basis of aging and discover new anti-aging therapeutic compounds or formulations to combat the detrimental effects of aging and promote a healthy life span. The budding yeast has been, and continues to be, an indispensable model organism in the field of biomedical research for discovering the molecular basis of aging has preserved nutritional signaling pathways (such as the target of rapamycin (TOR)-Sch9 and the Ras-AC-PKA (cAMP-dependent protein kinase) pathways, and shows two distinct aging paradigms chronological life span (CLS) and replicative life span (RLS).
View Article and Find Full Text PDFThe Anti-AGEing and RAGEing Potential of Isothiocyanates.
Molecules
December 2024
Department of Surgery, School of Medicine, Virginia Commonwealth University, Richmond, VA 23284, USA.
Isothiocyanates (ITCs), found in edible plants such as cruciferous vegetables, are a group of reactive organo-sulfur phytochemicals produced by the hydrolysis of precursors known as glucosinolates. ITCs have been studied extensively both in vivo and in vitro to define their therapeutic potential for the treatment of chronic health conditions. Therapeutically, they have shown an intrinsic ability to inhibit oxidative and inflammatory phenotypes to support enhanced health.
View Article and Find Full Text PDFLigand docking in the sigma-1 receptor compared to the sigma-1 receptor-BiP complex and the effects of agonists and antagonists on C. elegans lifespans.
Biomed Pharmacother
January 2025
Center of Excellence on Natural Products for Neuroprotection and Anti-Ageing, Chulalongkorn University, Bangkok 10330, Thailand; Research, Innovation and International Affairs, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand. Electronic address:
Model organisms are commonly used to study human diseases; we set out to understand the relevance of several model organisms with relation to the σ1R protein. The study explored the interactions of σ1R with various agonists, antagonists across different species. Ligand and protein-protein (σ1R-BiP) docking approaches were used to understand the significance of σ1R in modulating neuroprotective mechanisms and its potential role in Alzheimer's.
View Article and Find Full Text PDFLithocholic acid phenocopies anti-ageing effects of calorie restriction.
Nature
December 2024
State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Fujian, China.
Calorie restriction (CR) is a dietary intervention used to promote health and longevity. CR causes various metabolic changes in both the production and the circulation of metabolites; however, it remains unclear which altered metabolites account for the physiological benefits of CR. Here we use metabolomics to analyse metabolites that exhibit changes in abundance during CR and perform subsequent functional validation.
View Article and Find Full Text PDFResveratrol and Its Analogues: Anti-ageing Effects and Underlying Mechanisms.
Subcell Biochem
December 2024
School of Public Health, Sun Yat-Sen University, Guangzhou, China.
Ageing is a natural process accompanied by functional and structural decline of diverse tissues and organs, which could cause susceptibility to various diseases and death. The anti-ageing interventions have aroused huge research interest with the rapid rise of ageing population in the world. Resveratrol, a polyphenolic stilbene, could be naturally isolated from various plants, such as grapes, blueberries, and peanuts.
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