AI Article Synopsis
- - Ferroptosis is a type of cell death that relies on iron and involves the buildup of harmful lipid peroxides and reactive oxygen species.
- - This process is linked to conditions like pancreatic beta cell dysfunction and insulin resistance, which are key factors in the development of type 2 diabetes mellitus (T2DM).
- - The review focuses on how iron accumulation affects beta cell apoptosis (cell death) in T2DM, highlighting new findings on the connection between iron and beta cell health in diabetes.
Article Abstract
Ferroptosis is an iron-dependent death mode mediated by the aggregation of lipid peroxides and lipid-reactive oxygen species. It is characterized by iron-dependent lipid peroxide accumulation accompanied by oxidoreductase deficiency. Pancreatic beta cell dysfunction and insulin resistance are two major causes of type 2 diabetes mellitus (T2DM). Iron accumulation and metabolism may play a role in the development of T2DM. The molecular mechanism of β cell apoptosis and iron death in T2DM were reviewed. In addition, we discuss recent insights on the relationship between the trace element iron and apoptosis of β cells in T2DM.
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| http://dx.doi.org/10.1055/a-2122-5701 | DOI Listing |
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