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Evaluation of simple diagnostic parameters in acute kidney injury in hospitalized patients-diagnostic recommendations for non-nephrologists.
Intern Emerg Med
September 2023
Department of Internal Medicine, Nephrology & Intensive Care Medicine, Phillips University, Baldinger Straße 1, 35043, Marburg, Germany.
Acute kidney injury (AKI) is very common in hospitalized patients, affecting patient's mortality and morbidity. Major causes are prerenal AKI and acute tubular necrosis (ATN). Even though a variety of parameters/indices exist, their reliability and practicability are controversial: in fact, there is a need for a simple diagnostic approach for AKI in in-patients with parameters easily obtained in any hospital.
View Article and Find Full Text PDFUrine-to-plasma creatinine ratio and fractional excretion of urea performance in acute-on-chronic kidney disease patients.
J Nephrol
December 2023
Department of Nephrology, University Hospital of Reims, Reims, France.
Kidney Tubulointerstitial Fibrosis and Tubular Secretion.
Am J Kidney Dis
May 2022
Division of Nephrology-Hypertension, University of California San Diego, La Jolla.
Rationale & Objective: Tubular secretion plays an important role in the efficient elimination of endogenous solutes and medications, and lower secretory clearance is associated with risk of kidney function decline. We evaluated whether histopathologic quantification of interstitial fibrosis and tubular atrophy (IFTA) is associated with lower tubular secretory clearance in persons undergoing kidney biopsy.
Study Design: Cross-sectional.
Impaired Tubular Secretion of Organic Solutes in Advanced Chronic Kidney Disease.
J Am Soc Nephrol
November 2021
Department of Medicine, Stanford University, Palo Alto, California.
Background: The clearance of solutes removed by tubular secretion may be altered out of proportion to the GFR in CKD. Recent studies have described considerable variability in the secretory clearance of waste solutes relative to the GFR in patients with CKD.
Methods: To test the hypothesis that secretory clearance relative to GFR is reduced in patients approaching dialysis, we used metabolomic analysis to identify solutes in simultaneous urine and plasma samples from 16 patients with CKD and an eGFR of 7±2 ml/min per 1.
Assessment of kidney proximal tubular secretion in critical illness.
JCI Insight
May 2021
Kidney Research Institute, Division of Nephrology, Department of Medicine, University of Washington, Seattle, Washington, USA.
BACKGROUNDSerum creatinine concentrations (SCrs) are used to determine the presence and severity of acute kidney injury (AKI). SCr is primarily eliminated by glomerular filtration; however, most mechanisms of AKI in critical illness involve kidney proximal tubules, where tubular secretion occurs. Proximal tubular secretory clearance is not currently estimated in the intensive care unit (ICU).
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