Adults with coronary artery disease often have atherosclerosis, this is defined as the accumulation of plaque in the tissues of the arterial wall. Cardiologists utilize optical coherence tomography (OCT), a light-based imaging method, to examine the layers of intracoronary tissue along pathological formations, such as plaque accumulation. Intracoronary cross-sectional images produced by state-of-the-art catheter-based imaging scheme have 10-15 µm high resolution. Nevertheless, interpretation of the obtained images depends on the operator, which takes a lot of time and is exceedingly error-prone from one observer to another. OCT image post-processing that automatically and accurately tags coronary plaques can help the technique become more widely used and lower the diagnostic error rate. To overcome these problems, Atherosclerosis plaque tissue classification using Self-Attention-Based Conditional Variational Auto-Encoder Generative Adversarial Network (APC-OCTPI-SACVAGAN) is proposed which classifies the Atherosclerosis plaque images as Fibro calcific plaque, Fibro atheroma, Thrombus, Fibrous plaque and Micro-vessel. The proposed APC-OCTPI-SACVAGAN technique is executed in MATLAB. The efficiency of proposed APC-OCTPI-SACVAGAN method attains 16.19 %, 17.93 %, 19.81 % and 1.57 % higher accuracy; 16.92 %, 11.54 %, 5.29 % and 1.946 % higher Area under curve; and 28.06 %, 25.32 %, 32.19 % and 39.185 % lower computational time comparing to the existing methods respectively.
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http://dx.doi.org/10.1515/bmt-2022-0286 | DOI Listing |
J Am Heart Assoc
January 2025
Research Institute of Internal Medicine, Oslo University Hospital Oslo Norway.
Background: Complement activation may promote atherosclerosis. Yet, data on the to which extent complement, and more specifically the alternative complement pathway, is activated in patients with carotid atherosclerosis and related to adverse outcome in these patients, are scarce.
Methods And Results: We measured, by ELISA, plasma levels of factor D, properdin, C3bBbP (C3 convertase), and factor H in patients with advanced carotid atherosclerosis in a (n=324) and in a (n=206) cohort in relation to adverse outcome (mean follow-up 7.
Front Immunol
January 2025
Laboratory of Immunohematology, Department of Internal Medicine, Medical School, University of Patras, Patras, Greece.
Obesity is a rapidly growing health problem worldwide, affecting both adults and children and increasing the risk of chronic diseases such as type 2 diabetes, hypertension and cardiovascular disease (CVD). In addition, obesity is closely linked to chronic kidney disease (CKD) by either exacerbating diabetic complications or directly causing kidney damage. Obesity-related CKD is characterized by proteinuria, lipid accumulation, fibrosis and glomerulosclerosis, which can gradually impair kidney function.
View Article and Find Full Text PDFCo-existing neuropathological comorbidities have been repeatedly reported to be extremely common in subjects dying with dementia due to Alzheimer disease. As these are likely to be additive to cognitive impairment, and may not be affected by molecularly-specific AD therapeutics, they may cause significant inter-individual response heterogeneity amongst subjects in AD clinical trials. Furthermore, while originally noted for the oldest old, recent reports have now documented high neuropathological comorbidity prevalences in younger old AD subjects, who are more likely to be included in clinical trials.
View Article and Find Full Text PDFMater Today Bio
February 2025
Institute of Optical Functional Materials for Biomedical Imaging, School of Chemistry and Pharmaceutical Engineering, Shandong First Medical University & Shandong Academy of Medical Science, Taian, Shandong, 271016, PR China.
Cardiovascular diseases (CVDs) are a leading cause of mortality worldwide. As a chronic inflammatory disease with a complicated pathophysiology marked by abnormal lipid metabolism and arterial plaque formation, atherosclerosis is a major contributor to CVDs and can induce abrupt cardiac events. The discovery of exosomes' role in intercellular communication has sparked a great deal of interest in them recently.
View Article and Find Full Text PDFFront Neurol
January 2025
Department of Neurology, The Third Hospital of Hebei Medical University, Shijiazhuang, China.
Objective: Recent studies have indicated a close relationship between intracranial arterial stenosis and white matter hyperintensities (WMHs), but few have reported on the correlation between the characteristics of intracranial arterial wall plaques and WMHs. The aim of this study was to comprehensively assess the correlation between intracranial atherosclerosis plaques and WMHs using 3.0T high-resolution magnetic resonance imaging (HR-MRI).
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