AI Article Synopsis
- The study focused on creating and testing chlorhexidine:β-cyclodextrin (Chx:βCD) complexes for their antifungal properties.
- Physicochemical analysis showed that a 1:2 molar ratio of Chx:βCD was optimal for achieving antifungal activity against nine different fungal strains.
- When added to denture material, Chx:βCD demonstrated enhanced antifungal effectiveness, needing only 7.5% of Chx concentration to remain effective for 14 days, suggesting potential for new treatments for oral candidiasis and denture stomatitis.
Article Abstract
This study aimed to develop, characterize and analyze the antifungal activity of chlorhexidine:β-cyclodextrin inclusion complexes (Chx:βCD). Chx:βCD were characterized by physicochemical techniques and the susceptibility of nine strains was assessed. The inhibition of biofilm growth was evaluated in a denture material modified with the incorporation of Chx:βCD. Chx was better complexed in 1:2 molar ratio by freeze-drying. Chx:βCD presented antifungal activity against all strains. When incorporated into the denture material, Chx:βCD showed better antifungal activity, as it required about 7.5% of Chx concentration compared with the raw Chx for 14 days. The improved characteristics of Chx:βCD can result in new formulations to treat oral candidiasis and denture stomatitis.
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| http://dx.doi.org/10.4155/tde-2022-0068 | DOI Listing |
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