Background And Objectives: The effect of mogamulizumab in cutaneous T-cell lymphoma (CTCL) on T cells (TC) in the peripheral blood and its potential role to navigate treatment intervals are explored.
Methods: We investigated within a retrospective monocentric analysis the effect of mogamulizumab on the CD3 TC and the aberrant T cell population (TCP), i.e., the CD4 /CD7 and the CD4 /CD26 TC, analyzed by flow cytometry.
Results: Thirteen patients with CTCL were included. After four cycles there was a mean reduction of 57% in CD3 TC, 72% in the CD4 /CD7 and 75% in the CD4 /CD26 TCP compared to the individual baseline of each patient. The reduction in CD4 /CD7 and CD4 /CD26 TC was lower, averaging 54% and 41%. A significant decrease in aberrant TCP was already evident after the first administration. A median plateau of TCP already occurred during the IP. Progressive disease occurred in 5/13 patients without a clear correlation to aberrant TCP.
Conclusions: Already after one dose of mogamulizumab, aberrant TCP and, to a lesser extent, normal TC decrease. We did not observe a clear correlation between TCP and the efficacy of mogamulizumab, but further studies with larger numbers of patients are needed.
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