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Synaptic architecture of leg and wing premotor control networks in . | LitMetric

AI Article Synopsis

  • Animal movement is driven by motor neurons that connect the central nervous system to muscles, with complex premotor networks coordinating their activity for various behaviors.
  • The study examines the connectomics of these premotor circuits for legs and wings, revealing that leg networks feature modules that align MNs with similar functions and have proportional synaptic weights.
  • In contrast, wing premotor networks display different connectivity patterns that allow for flexible timing in muscle recruitment, showcasing both shared principles and unique adaptations in motor control between limbs.

Article Abstract

Animal movement is controlled by motor neurons (MNs), which project out of the central nervous system to activate muscles. MN activity is coordinated by complex premotor networks that allow individual muscles to contribute to many different behaviors. Here, we use connectomics to analyze the wiring logic of premotor circuits controlling the leg and wing. We find that both premotor networks cluster into modules that link MNs innervating muscles with related functions. Within most leg motor modules, the synaptic weights of each premotor neuron are proportional to the size of their target MNs, establishing a circuit basis for hierarchical MN recruitment. In contrast, wing premotor networks lack proportional synaptic connectivity, which may allow wing steering muscles to be recruited with different relative timing. By comparing the architecture of distinct limb motor control systems within the same animal, we identify common principles of premotor network organization and specializations that reflect the unique biomechanical constraints and evolutionary origins of leg and wing motor control.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312524PMC
http://dx.doi.org/10.1101/2023.05.30.542725DOI Listing

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