In the contemporary era, a significant number of individuals encounter various health issues, including digestive system ailments, even during their advanced years. The major purpose of this study is based on certain observations that are made in internal digestive systems in order to prevent severe cause that usually occurs in elderly people. To solve the purpose of the proposed method the proposed system is introduced with advanced features and parametric monitoring system that are based on wireless sensor setups. The parametric monitoring system is integrated with neural network where certain control actions are taken to prevent gastrointestinal activities at reduced data loss. The outcome of the combined process is examined based on four different cases that is designed based on analytical model where control parameters and weight establishments are also determined. As the internal digestive system is monitored the data loss that is present with wireless sensor network must be reduced and proposed approach prevents such data loss with an optimized value of 1.39%. Parametric cases were conducted to evaluate the efficacy of neural networks. The findings indicate a significantly higher effectiveness rate of approximately 68% when compared to the control cases.
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http://dx.doi.org/10.3389/fbioe.2023.1211143 | DOI Listing |
J Clin Invest
January 2025
Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota, Minneapolis, United States of America.
Eccentric contraction- (ECC) induced force loss is a hallmark of murine dystrophin-deficient (mdx) skeletal muscle that is used to assess efficacy of potential therapies for Duchenne muscular dystrophy. While virtually all key proteins involved in muscle contraction have been implicated in ECC force loss, a unifying mechanism that orchestrates force loss across such diverse molecular targets has not been identified. We showed that correcting defective hydrogen sulfide (H2S) signaling in mdx muscle prevented ECC force loss.
View Article and Find Full Text PDFFront Med
January 2025
Department of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, China.
SMARCA4-deficient non small cell lung cancer (SMARCA4-dNSCLC) has recently garnered increasing attention due to its high malignancy and poor prognosis. The literature suggests that in non small cell lung cancer (NSCLC), the loss of SMARCA4 frequently co-occurs with mutations in KRAS, KEAP1, and STK11 rather than in EGFR, ALK, and ROS1. Herein, we present the first documented case of SMARCA4-dNSCLC accompanied with rare mutations of EGFR exon 20 S768I and exon 18 G719X.
View Article and Find Full Text PDFInt Urol Nephrol
January 2025
Department of Urology, Zealand University Hospital, Roskilde, Denmark.
Objective: To compare operative and oncological outcomes, as well as the risk of postoperative complications in patients who underwent transperitoneal robot-assisted partial nephrectomy (RAPN) for renal tumours located either posteriorly or anterolaterally.
Methods: Retrospective, consecutive study including 451 patients who underwent transperitoneal RAPN for non-metastatic, localised renal tumours from May 2016 to April 2023. Operative data included duration of the procedure, warm ischaemia time, and blood loss; oncological data included surgical margins and recurrence; and 90-day postoperative complications were classified according to the Clavien-Dindo classification.
J Gerontol B Psychol Sci Soc Sci
January 2025
Centre for Population Health Research and Implementation, Singapore Health Services, Singapore, Singapore.
Objectives: Restriction of life space mobility is associated with adverse health outcomes including depression, morbidity, mortality and poorer quality of life. In this study, we aimed to determine the impact of COVID-19 and associated employment loss on the life space of older adults in Singapore.
Methods: An in-person survey was administered to a cohort of older Singaporeans above 50 years old (N = 1,118).
Cochrane Database Syst Rev
January 2025
Cochrane Kidney and Transplant, Centre for Kidney Research, The Children's Hospital at Westmead, Westmead, Australia.
Background: Cytomegalovirus (CMV) is a significant cause of morbidity and death in solid organ transplant recipients. Pre-emptive treatment of patients with CMV viraemia using antiviral agents has been suggested as an alternative to routine prophylaxis to prevent CMV disease. This is an update of a Cochrane review first published in 2006 and updated in 2013.
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