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The Therapeutic Potential of Intra-Articular Injection of Synthetic Deer Antler Peptides in a Rat Model of Knee Osteoarthritis.
Int J Mol Sci
May 2024
Institute of Medical Sciences, Tzu Chi University, Hualien 970374, Taiwan.
Synthetic deer antler peptides (TSKYR, TSK, and YR) stimulate the proliferation of human chondrocytes and osteoblasts and increase the chondrocyte content of collagen and glycosamino-glycan in vitro. This study investigated the peptide mixture's pain relief and chondroprotective effect in a rat model of collagenase-induced osteoarthritis. Thirty-six adult male Sprague-Dawley rats were divided into three groups: control (saline), positive control (hyaluronic acid), and ex-perimental (peptides).
View Article and Find Full Text PDFBiological Activities of Deer Antler-Derived Peptides on Human Chondrocyte and Bone Metabolism.
Pharmaceuticals (Basel)
March 2024
Integration Center of Traditional Chinese and Modern Medicine, Hualien Tzu Chi Hospital, Hualien 970473, Taiwan.
Orally administered "tortoiseshell and deer antler gelatin" is a common traditional medicine for patients with osteoporosis or osteoarthritis. From the pepsin-digested gelatin, we previously isolated and identified the osteoblast-stimulating pentapeptide, TSKYR. Its trypsin digestion products include the dipeptide YR, enhancing calcium ion uptake, and tripeptide TSK, resulting in remarkable 30- and 50-fold increases in mineralized nodule area and density in human osteoblast cells.
View Article and Find Full Text PDFMechanistic insights on the antibacterial action of the kyotorphin peptide derivatives revealed by in vitro studies and Galleria mellonella proteomic analysis.
Microb Pathog
April 2024
Laboratório de Bioquímica de Peptídeos, Departamento de Ciência e Tecnologia - Universidade Federal de São Paulo - UNIFESP, Rua Talim, 330, São José dos Campos, SP, 12231-280, Brazil. Electronic address:
Objectives: The selected kyotorphin derivatives were tested to improve their antimicrobial and antibiofilm activity. The antimicrobial screening of the KTP derivatives were ascertained in the representative strains of bacteria, including Streptococcus pneumoniae, Streptococcus pyogenes, Escherichia coli and Pseudomonas aeruginosa.
Methods: Kyotorphin derivatives, KTP-NH, KTP-NH-DL, IbKTP, IbKTP-NH, MetKTP-DL, MetKTP-LD, were designed and synthesized to improve lipophilicity and resistance to enzymatic degradation.
Lactic acid fermentation of goji berries () prevents acute alcohol liver injury and modulates gut microbiota and metabolites in mice.
Food Funct
February 2024
Department of Gastroenterology, Affiliated Hospital of Jiangnan University, Wuxi, China.
Juice fermented with lactic acid bacteria (LAB) has received attention due to its health benefits, such as antioxidant and anti-inflammatory. Previous research on LAB-fermented goji juice mainly focused on exploring the changes in the metabolite profile and antioxidant activity , whereas the liver protection properties of LAB-fermented goji juice are still unknown. This study aimed to investigate the effects of E10-fermented goji juice (E10F), M-fermented goji juice (MF), LGG-fermented goji juice (LGGF) on preventing acute alcoholic liver injury with physiology, gut microbial, and metabolic profiles in mice.
View Article and Find Full Text PDFIsolation, Identification, and Characterization of Bioactive Peptides in Human Bone Cells from Tortoiseshell and Deer Antler Gelatin.
Int J Mol Sci
January 2023
Integration Center of Traditional Chinese and Modern Medicine, Hualien Tzu Chi Hospital, Hualien 970473, Taiwan.
Tortoiseshell and deer antler gelatin has been used to treat bone diseases in Chinese society. A pepsin-digested gelatin peptide with osteoblast-proliferation-stimulating properties was identified via LC-MS/MS. The resulting pentapeptide, TSKYR, was presumably subjected to further degradation into TSKY, TSK, and YR fragments in the small intestine.
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