Multidrug-resistant/extensively drug-resistant (MDR/XDR) Pseudomonas aeruginosa (PA) are critical antimicrobial resistance threats. Despite their increasing prevalence, treatment options for metallo-β-lactamase (MBL)-producing PA are limited, especially for New Delhi metallo-β-lactamase (NDM) producers. Pending further clinical studies, this case provides support for limited-scope use of cefepime-zidebactam for treating disseminated infections secondary to NDM-producing XDR PA. Susceptibilities should be tested and/or alternative regimens considered when treating isolates with alternative MBLs or increased efflux pump expression because some data suggest associated loss of cefepime-zidebactam susceptibility.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433852 | PMC |
| http://dx.doi.org/10.1128/aac.00663-23 | DOI Listing |
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