AI Article Synopsis
- This study explores the effects of Globin digest (GD) on physical fatigue, revealing that it may help combat fatigue caused by forced exercise.
- Administering GD and its components, valine and others, for five days improved locomotion in mice and lowered blood lactate levels.
- The findings suggest that GD's anti-fatigue effects could be linked to the activation of a protein called AMPK in muscle, which helps manage energy and fatigue responses.
Article Abstract
Globin digest (GD) inhibits dietary hypertriglyceridemia; however, its effects on physical fatigue remain unknown. Therefore, this study aimed to investigate the potential anti-fatigue effects of GD. Repeated administration of GD and valine (Val)-Val-tyrosine (Tyr)-proline (Pro), a component of GD, for five days prevented the forced walking-induced decrease in locomotion. Furthermore, GD treatment reversed the forced walking-induced increase in blood lactate levels in mice and increased phosphorylated AMP-activated protein kinase (p-AMPK) in the soleus muscle, suggesting that the anti-fatigue effect of GD involves AMPK activation in the soleus muscle through reduced blood lactate.
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| http://dx.doi.org/10.1248/bpb.b23-00193 | DOI Listing |
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