Inositol 1,4,5-trisphosphate receptors (IPRs) are ubiquitously expressed large-conductance Ca-permeable channels predominantly localized to the endoplasmic reticulum (ER) membranes of virtually all eukaryotic cell types. IPRs work as Ca signaling hubs through which diverse extracellular stimuli and intracellular inputs are processed and then integrated to result in delivery of Ca from the ER lumen to generate cytosolic Ca signals with precise temporal and spatial properties. IPR-mediated Ca signals control a vast repertoire of cellular functions ranging from gene transcription and secretion to the more enigmatic brain activities such as learning and memory. IPRs open and release Ca when they bind both IP and Ca, the primary channel agonists. Despite overwhelming evidence supporting functional interplay between IP and Ca in activation and inhibition of IPRs, the mechanistic understanding of how IPR channels convey their gating through the interplay of two primary agonists remains one of the major puzzles in the field. The last decade has seen much progress in the use of cryogenic electron microscopy to elucidate the molecular mechanisms of ligand binding, ion permeation, ion selectivity and gating of the IPR channels. The results of these studies, summarized in this review, provide a prospective view of what the future holds in structural and functional research of IPRs.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529787 | PMC |
http://dx.doi.org/10.1016/j.ceca.2023.102770 | DOI Listing |
Heliyon
October 2024
University of Chinese Academy of Sciences, Beijing, 101408, China.
The pore throat size, structure distribution, and lithology of porous media in gas reservoirs are varied, and the gas-water two-phase seepage law is complex, making it difficult to describe the seepage model. Newton's law of motion is a basic law of motion in classical mechanics, and its application in gas-water two-phase seepage modeling is an innovative practice of classical mechanics in seepage mechanics systems. Based on Newton's three laws of motion, a gas-water two-phase seepage model was established from the force analysis of fluid, and the relationship between velocity and pressure difference, pipe radius, water film thickness, viscosity, etc.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
November 2024
School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules and State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai, 200240, China.
Biomed Opt Express
October 2024
Universität zu Lübeck, Institut für Biomedizinische Optik (BMO), Peter-Monnik-Weg 4, 23562 Lübeck, Germany.
Neurosurgical interventions on the brain are impeded by the requirement to keep damages to healthy tissue at a minimum. A new contrast channel enhancing the visual separation of malign tissue should be created. A commercially available surgical microscope was modified with adaptation optics adapting the MHz speed optical coherence tomography (OCT) imaging system developed in our group.
View Article and Find Full Text PDFCell Biochem Biophys
December 2024
Department of Mathematics, School of Technology, Pandit Deendayal Energy University, Gandhinagar, Gujarat, India.
Calcium plays a crucial role as a second messenger in neuronal signal transduction pathways. The influx of calcium ions through various physicochemical gating channels activates neuronal calcium signaling. The Endoplasmic Reticulum (ER) is a significant intracellular structure that sequesters calcium and controls signaling through SERCA, IPR, and leak channel mechanisms.
View Article and Find Full Text PDFNat Commun
May 2024
Institute of Pure and Applied Science and Tsukuba Research Center for Energy Materials Science (TREMS), University of Tsukuba, Tsukuba, 305-8573, Japan.
Electron transfer is a fundamental energy conversion process widely present in synthetic, industrial, and natural systems. Understanding the electron transfer process is important to exploit the uniqueness of the low-dimensional van der Waals (vdW) heterostructures because interlayer electron transfer produces the function of this class of material. Here, we show the occurrence of an electron transfer process in one-dimensional layer-stacking of carbon nanotubes (CNTs) and boron nitride nanotubes (BNNTs).
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!