Objective: To characterize demographics and trends in length of stay (LOS), morbidities, and mortality in late preterm infants.
Study Design: Cohort study of infants born between 34 and 36 weeks gestation between 1999 and 2018 without major congenital anomalies at Pediatrix Medical Group neonatal intensive care units (NICUs).
Results: 307,967 infants from 410 NICUs met inclusion criteria. The median (25-75 percentile) LOS was 11 (8-16) days in the entire period. Postmenstrual age (PMA) at discharge increased during the cohort for all gestational ages (p < 0.001). There was a decrease in invasive ventilation, receipt of phototherapy, and reflux medications observed (p < 0.001).
Conclusion: In this large cohort, given 20 years of time for medical advancement, there was no significant improvement in the LOS of late preterm infants. All infants had an increased PMA at discharge, despite multiple practice changes that were observed.
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http://dx.doi.org/10.1038/s41372-023-01705-5 | DOI Listing |
J Crit Care Med (Targu Mures)
October 2024
Department of Obstetrics and Gynecology, "Victor Babes" University of Medicine and Pharmacy, Timișoara, Romania.
Background: Neonatal sepsis is a serious condition with high rates of morbidity and mortality, caused by the rapid growth of microorganisms that trigger a systemic reaction. Symptoms can range from mild to severe presentations. The causative microorganism is usually transmitted from mothers, especially from the urogenital tract, or can originate from the community or hospital.
View Article and Find Full Text PDFIntroduction: Despite the increasing evidence supporting the use of biologics for treating severe asthma, there is a lack of evidence regarding their use in pregnant women. This study aims to evaluate the safety of biologics for pregnant women, utilizing global pharmacovigilance database.
Methods: Reports documented between 1980 and 2023 were extracted from the VigiBase that mentioned pregnancy- or fetus-related reactions with drugs indicated for asthma, including reslizumab, omalizumab, mepolizumab, dupilumab, benralizumab, and other non-biologics.
Early Hum Dev
January 2025
Division of Neonatology, Department of Pediatrics, Saint Elizabeth's Medical Center, Brighton, MA 02135, United States of America.
Background: Preterm infants are at risk for necrotizing enterocolitis (NEC) and sepsis. Optimal strategies of preterm feeding to achieve full enteral feeding early with minimal duration of central lines without increasing the risk of NEC remain uncertain. We aimed to evaluate if new enteral feeding strategies reflecting early initiation, fortification, and more rapid advancement is beneficial without increasing the risk of NEC.
View Article and Find Full Text PDFEarly Hum Dev
January 2025
Department of Pediatrics, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel; Neonatal Intensive Care Unit, Rambam Health Care Campus, Israel. Electronic address:
Background: Preterm birth, particularly with lower gestational age and respiratory complications, can impact neurodevelopmental outcomes and participation in daily activities. Understanding how these children engage in everyday tasks, particularly from the perspective of their parents, is critical for assessing long-term health outcomes and quality of life.
Objectives: This study aims to assess parental perceptions of participation and daily performance in children born preterm, comparing early preterm infants with and without chronic lung disease, late preterms, and term-born children.
Int J Gynaecol Obstet
January 2025
Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Background: Prematurity complications are a leading cause of mortality and morbidity in offspring, including adverse neurodevelopmental outcomes. The association between preterm birth (PTB) and autism spectrum disorder (ASD) remains debated.
Objective: To investigate the association between PTB and ASD diagnosis during childhood.
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