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Background And Aims: Ulcerative proctitis [UP] is an uncommon presentation in paediatric patients with ulcerative colitis. We aimed to characterize the clinical features and natural history of UP in children, and to identify predictors of poor outcomes.
Methods: This was a retrospective study involving 37 sites affiliated with the IBD Porto Group of ESPGHAN. Data were collected from patients aged <18 years diagnosed with UP between January 1, 2016 and December 31, 2020.
Results: We identified 196 patients with UP (median age at diagnosis 14.6 years [interquartile range, IQR 12.5-16.0]), with a median follow-up of 2.7 years [IQR 1.7-3.8]. The most common presenting symptoms were bloody stools [95%], abdominal pain [61%] and diarrhoea [47%]. At diagnosis, the median paediatric ulcerative colitis activity index [PUCAI] score was 25 [IQR 20-35], but most patients exhibited moderate-severe endoscopic inflammation. By the end of induction, 5-aminosalicylic acid administration orally, topically or both resulted in clinical remission rates of 48%, 48%, and 73%, respectively. The rates of treatment escalation to biologics at 1, 3, and 5 years were 10%, 22%, and 43%, respectively. In multivariate analysis, the PUCAI score at diagnosis was significantly associated with initiation of systemic steroids, or biologics, and subsequent acute severe colitis events and inflammatory bowel disease-associated admission, with a score ≥35 providing an increased risk for poor outcomes. By the end of follow-up, 3.1% of patients underwent colectomy. Patients with UP that experienced proximal disease progression during follow-up [48%] had significantly higher rates of a caecal patch at diagnosis and higher PUCAI score by the end of induction, compared to those without progression.
Conclusion: Paediatric patients with UP exhibit high rates of treatment escalation and proximal disease extension.
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http://dx.doi.org/10.1093/ecco-jcc/jjad111 | DOI Listing |
J Neural Eng
December 2024
West China Hospital of Sichuan University, No.37 Guoxue Alley, Wuhou District, Chengdu City, Sichuan Province, Chengdu, Sichuan, 610041, CHINA.
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Department of Instrumentation and Control Engineering, Dr B R Ambedkar National Institute of Technology Jalandhar, Punjab, 144008, India.
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December 2024
Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, 410013, China.
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View Article and Find Full Text PDFBlood Res
December 2024
Department of Surgery, Division of HBP Surgery, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-Gu, Seoul, 03080, Republic of Korea.
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View Article and Find Full Text PDFJ Cardiovasc Transl Res
December 2024
Department of Cardiovascular Surgery, The Yancheng School of Clinical Medicine of Nanjing Medical University, 02 Xinduxi Road, Yancheng, 224000, China.
This study aimed to construct machine learning models and predict prolonged intensive care units (ICU) stay in patients receiving perioperative intra-aortic balloon pump (IABP) therapy during cardiac surgery. 236 patients were divided into the normal (≤ 14 days) and prolonged (> 14 days) ICU groups based on the 75th percentile of ICU duration across the entire cohort. Seven machine learning models were trained and validated.
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