AI Article Synopsis
- The review highlights how the accumulation of phosphorylated tau is a key feature of tauopathies like Alzheimer's disease, with different tau isoforms found in various cell types and brain regions.* -
- It showcases advancements in analytical methods, particularly mass-spectrometry and Phos-tag technology, which help in studying the post-translational modifications of tau, mainly focusing on phosphorylation and its structural variations in different tauopathies revealed by cryo-EM.* -
- The article also emphasizes progress in identifying biofluid and imaging biomarkers for tauopathy, aiming to enhance diagnostics and understanding of the disease's progression.*
Article Abstract
The deposition of highly phosphorylated and aggregated tau is a characteristic of tauopathies, including Alzheimer's disease. It has long been known that different isoforms of tau are aggregated in different cell types and brain regions in each tauopathy. Recent advances in analytical techniques revealed the details of the biochemical and structural biological differences of tau specific to each tauopathy. In this review, we explain recent advances in the analysis of post-translational modifications of tau, particularly phosphorylation, brought about by the development of mass-spectrometry and Phos-tag technology. We then discuss the structure of tau filaments in each tauopathy revealed by the advent of cryo-EM. Finally, we describe the progress in biofluid and imaging biomarkers for tauopathy. This review summarizes current efforts to elucidate the characteristics of pathological tau and the landscape of the use of tau as a biomarker to diagnose and determine the pathological stage of tauopathy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10839341 | PMC |
| http://dx.doi.org/10.1002/2211-5463.13667 | DOI Listing |
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