The complete hematological remission (CHR) rate, duration of remission and survival were studied in relation to age, peripheral blast cell (PBC) count, presence or absence of tumor masses, cytological type, and treatment in 650 patients with acute lymphoblastic leukemia. Prognostic factors were considered separately and divided into prognostic classes. Age and PCB count correlated with both the rate and the duration of CHR. This correlation was still observed for more recent treatment schedules though it appears to be becoming progressively less significant. Meningeal relapses were more common in patients less than 1 year old and in those with a high PCB count. It is suggested that stratification of patients according to such factors as age, PCB count, presence or absence of tumor, and cytological type might be necessary for the design of new treatment protocols and for the evaluation of their results.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/BF00254045 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of polystyrene micro/nanoplastics on PCBs removal in constructed wetlands planted with Myriophyllum aquaticum.
Environ Res
January 2025
State Key Laboratory of Organic Geochemistry and Guangdong-Hong Kong-Macao Joint Laboratory for Environmental Pollution and Control, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China. Electronic address:
The co-occurrence of microplastics (MPs) and nanoplastics (NPs) with polychlorinated biphenyls (PCBs) is an emerging environmental concern. Wetland plants, with their unique anaerobic-aerobic environments, offer a promising approach for PCBs removal. However, the impact of MPs and NPs on PCBs dynamics in constructed wetlands is not well understood.
View Article and Find Full Text PDFAn Innovative 3D-IDE Design and Adaptive Signal Extraction Algorithm for Efficient Ovarian Cancer Detection.
ACS Appl Mater Interfaces
December 2024
Department of Electrical Engineering, Indian Institute of Technology, Hyderabad, Telangana 502285, India.
This work presents a facile, ultrasensitive, and selective chemiresistive biosensor assisted by an adaptive signal extraction algorithm (ASEA) for detecting vimentin, a potential biomarker for ovarian cancer detection. The low-cost device, fabricated on a PCB substrate through sacrificial copper etching, features a 3D-IDE design with interwoven comb-like structures mimicking the natural symmetry of a droplet. An unequal count of positive and negative concentric circle fingers ensures a uniform, higher electric field over the sensor's surface, as verified by COMSOL Multiphysics 3D simulation.
View Article and Find Full Text PDFThe association of organochlorine pesticides and polychlorinated biphenyls exposure with dyslipidemia and blood lipids: The mediating effect of white blood cell counts.
Environ Pollut
December 2024
State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei, 430030, China. Electronic address:
Epidemiological evidence regarding the associations of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) with lipid metabolism and its potential biological mechanisms remain largely unknown. We intended to explore the associations of OCPs and PCBs with dyslipidemia and blood lipid levels, and further evaluate the mediating role of total and differential white blood cell (WBC) counts. We measured the blood lipid levels, the concentration of OCPs/PCBs and WBC counts in serum among 2036 adults in Wuhan city, China.
View Article and Find Full Text PDFCombined effects of microfibers and polychlorinated biphenyls on the immune function of hemocytes in the mussel Mytilus coruscus.
Mar Environ Res
November 2023
International Research Center for Marine Biosciences at Shanghai Ocean University, Ministry of Science and Technology, Shanghai Ocean University, Shanghai, 201306, China; State Key Laboratory of Satellite Ocean Environment Dynamics, Second Institute of Oceanography, Ministry of Natural Resources, Hangzhou, 310012, China; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai, 201306, China. Electronic address:
Numerous studies have shown that microplastics can interact with other pollutants in the environment to produce synergistic effects, leading to more serious impacts. To date, there is little consensus on the combined effects of microfibers (MFs) and polychlorinated biphenyls (PCBs, Aroclor 1254), two legacy and alarming environmental pollutants. There is an urgent need to assess the impact of combined exposures on bivalve immune defences.
View Article and Find Full Text PDFChildhood Acute Lymphoblastic Leukemia: Results of the Randomized Acute Lymphoblastic Leukemia Intercontinental-Berlin-Frankfurt-Münster 2009 Trial.
J Clin Oncol
July 2023
Department of Pediatric and Adolescent Medicine, University Medical Center Schleswig-Holstein, Kiel, Germany.
Article Synopsis
- - The study analyzed 6,187 pediatric patients with acute lymphoblastic leukemia (ALL), focusing on minimal residual disease (MRD) assessment through flow cytometry (FCM) and the effects of different methotrexate (MTX) doses on survival rates.
- - Key findings revealed that 5-year event-free survival (EFS) rates were 75.2%, with variations based on risk groups: standard risk (90.7%), intermediate risk (77.9%), and high risk (60.8%).
- - Results indicated that MRD could be effectively assessed with FCM, and that while both MTX doses tested were similarly effective, the augmented treatment protocol showed no significant survival benefits over the standard
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!