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Substance P and dopamine form a "push-pull" system that diurnally regulates retinal gain.
Curr Biol
November 2024
Neuroscience, School of Life Sciences, University of Sussex, Sussex, Brighton BN19QG, UK. Electronic address:
Article Synopsis
- * Substance P is identified as another significant modulator in the retina that interacts with the dopamine system, impacting how visual information is processed.
- * In the morning, substance P reduces contrast sensitivity and overall visual information flow by suppressing dopamine's effects, particularly affecting how visual signals are processed through specific channels.
Norepinephrine Neurons in the Nucleus of the Solitary Tract Suppress Luteinizing Hormone Secretion in Female Mice.
J Neurosci
August 2024
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Diego, La Jolla, California 92093
Stress impairs fertility, at least in part, via inhibition of gonadotropin secretion. Luteinizing hormone (LH) is an important gonadotropin that is released in a pulsatile pattern in males and in females throughout the majority of the ovarian cycle. Several models of stress, including acute metabolic stress, suppress LH pulses via inhibition of neurons in the arcuate nucleus of the hypothalamus that coexpress kisspeptin, neurokinin B, and dynorphin (termed KNDy cells) which form the pulse generator.
View Article and Find Full Text PDFEffects of Bradykinin B2 Receptor Ablation from Tyrosine Hydroxylase Cells on Behavioral and Motor Aspects in Male and Female Mice.
Int J Mol Sci
January 2024
Department of Neurology and Neurosurgery, Federal University of Sao Paulo, Sao Paulo 04039-032, Brazil.
The kallikrein-kinin system is a versatile regulatory network implicated in various biological processes encompassing inflammation, nociception, blood pressure control, and central nervous system functions. Its physiological impact is mediated through G-protein-coupled transmembrane receptors, specifically the B1 and B2 receptors. Dopamine, a key catecholamine neurotransmitter widely distributed in the CNS, plays a crucial role in diverse physiological functions including motricity, reward, anxiety, fear, feeding, sleep, and arousal.
View Article and Find Full Text PDFIcatibant averting mechanical ventilation in acute ischemic stroke patient with alteplase-induced orolingual angioedema.
Eur J Neurol
April 2024
Second Department of Neurology, School of Medicine, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Background And Purpose: Orolingual angioedema (OA) represents a rare but life-threatening complication among patients with acute ischemic stroke treated with intravenous thrombolysis with alteplase. Novel agents, including icatibant, are recommended in resistant patients with alteplase-induced OA who have failed to respond to first-line therapies including corticosteroids, antihistamines, and/or adrenaline.
Methods: We present a patient with alteplase-induced OA who showed substantial clinical improvement following the administration of icatibant.
What Is Carcinoid Syndrome? A Critical Appraisal of Its Proposed Mediators.
Endocr Rev
May 2024
ENETS Center of Excellence, Section of Endocrinology, Department of Internal Medicine, Erasmus MC & Erasmus MC Cancer Institute, 3015 GD Rotterdam, The Netherlands.
Carcinoid syndrome (CS) is a debilitating disease that affects approximately 20% of patients with neuroendocrine neoplasms (NEN). Due to the increasing incidence and improved overall survival of patients with NEN over recent decades, patients are increasingly suffering from chronic and refractory CS symptoms. At present, symptom control is hampered by an incomplete understanding of the pathophysiology of this syndrome.
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