Focused ultrasound (FUS) has emerged as a promising area of research in neuro-oncology. Preclinical and clinical investigation has demonstrated the utility of FUS in therapeutic applications including blood brain barrier disruption for therapeutic delivery, and high intensity FUS for tumor ablation. However, FUS as it exists today is relatively invasive as implantable devices are necessary to achieve adequate intracranial penetration. Sonolucent implants, composed of materials permeable to acoustic waves, have been used for cranioplasty and intracranial imaging with ultrasound. Given the overlap in ultrasound parameters with those used for intracranial imaging, and the demonstrated efficacy of sonolucent cranial implants, we believe that therapeutic FUS through sonolucent implants represents a promising avenue of future research. The potential applications of FUS and sonolucent cranial implants may confer the demonstrated therapeutic benefits of existing FUS applications, without the drawbacks and complications of invasive implantable devices. Here we briefly summarize existing evidence regarding sonolucent implants and describe applications for therapeutic FUS.
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http://dx.doi.org/10.1016/j.jocn.2023.06.016 | DOI Listing |
Nano Lett
December 2024
School of Physical Science and Technology, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai, 201210, P. R. China.
Focused ultrasound (FUS) is a recognized tool that can be used clinically for the thermal ablation of tumors. However, excessive heat can cause side effects on the ultrasound transmission path and normal tissues around the tumor. To address the issue, this work detected for the first time the effect of microscopic heating of nanoparticles under the action of FUS through the luminescence intensity ratio (LIR) and luminescence lifetime of temperature-responsive lanthanide-doped nanoparticles.
View Article and Find Full Text PDFMedicine (Baltimore)
December 2024
The Community Health Service Center of Jingan in Qixia District, Nanjing, China.
Rationale: Fu's subcutaneous needling (FSN) is a special acupuncture method that uses FSN to sweep the subcutaneous tissue around or adjacent to the limbs to disperse the pain. Sudden sensorineural hearing loss (SSHL) is a kind of otological emergency with sudden onset within 72 hours, with unilateral hearing loss, and hearing loss of ≥20 dB in 2 connected frequencies, and most of the patients have no obvious triggers. Most patients with SSHL are accompanied by tinnitus, vertigo, and nausea and vomiting.
View Article and Find Full Text PDFExpert Rev Neurother
December 2024
Harquail Centre for Neuromodulation, Hurvitz Brain Sciences Program, Sunnybrook Research, Institute, Toronto, ON, Canada.
Introduction: Post-traumaticstress disorder (PTSD) can have debilitating effects on quality of life, andconventional treatments show mixed results. Neuromodulation is emerging as apromising approach for treating PTSD. This review examines currentneuromodulatory treatments for PTSD, and highlights methodologies, clinicaloutcomes, and gaps in the literature to help guide future research.
View Article and Find Full Text PDFMath Biosci Eng
October 2024
Department of Mechanical and Mechatronics Engineering, University of Waterloo, 200 University Avenue West, Waterloo, ON N2L 3G1, Canada.
This study presented a novel approach for the precise ablation of breast tumors using focused ultrasound (FUS), leveraging a physics-informed neural network (PINN) integrated with a realistic breast model. FUS has shown significant promise in treating breast tumors by effectively targeting and ablating cancerous tissue. This technique employs concentrated ultrasonic waves to generate intense heat, effectively destroying cancerous tissue.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy.
One of the most used chemotherapy agents in clinical practice is 5-Fluorouracil (5-FU), a fluorinated pyrimidine in the category of antimetabolite agents. 5-FU is used to treat a variety of cancers, including colon, breast, pancreatic, and stomach cancers, and its efficacy lies in its direct impact on the patient's DNA and RNA. Specifically, its mechanism blocks the enzymes thymidylate synthetase and uracil phosphatase, inhibiting the synthesis of uracil, which cannot be incorporated into nuclear and cytoplasmic RNA.
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