AI Article Synopsis
- A new way to create C-N bonds has been developed using tetrazoles, azides, and boronic acids, with iron as the catalyst.
- This method employs a unique metalloradical activation mechanism instead of the conventional metal-catalyzed techniques.
- The research shows that this strategy can effectively synthesize various compounds, including drug candidates, which could be highly beneficial for medicinal chemistry and pharmaceuticals.
Article Abstract
A concept for intermolecular C-N cross-coupling amination has been discovered using tetrazoles and aromatic and aliphatic azides with boronic acids under iron-catalyzed conditions. The amination follows an unprecedented metalloradical activation mechanism that is different from traditional metal-catalyzed C-N cross-coupling reactions. The scope of the reaction has been demonstrated by the employment of a large number of tetrazoles, azides, and boronic acids. Moreover, several late-stage aminations and a short synthesis of a drug candidate have been showcased for further synthetic utility. Collectively, this iron-catalyzed C-N cross-coupling should have wide applications in the context of medicinal chemistry, drug discovery, and pharmaceutical industries.
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| http://dx.doi.org/10.1021/jacs.3c05627 | DOI Listing |
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