AI Article Synopsis
- Spondweni virus (SPONV) is closely related to Zika virus (ZIKV) and has similar effects in pregnant mice; both are transmitted by mosquitoes.
- Research using cynomolgus and rhesus macaques revealed that while cynomolgus macaques are resistant to SPONV, rhesus macaques can be infected by both viruses and produce strong immune responses.
- The study indicates that immunity from ZIKV doesn't protect against SPONV, but ZIKV immunity does protect against SPONV infection, implying low risk for SPONV emergence in areas where ZIKV is prevalent due to this one-way cross-protection.
Article Abstract
Spondweni virus (SPONV) is the closest known relative of Zika virus (ZIKV). SPONV pathogenesis resembles that of ZIKV in pregnant mice, and both viruses are transmitted by mosquitoes. We aimed to develop a translational model to further understand SPONV transmission and pathogenesis. We found that cynomolgus macaques () inoculated with ZIKV or SPONV were susceptible to ZIKV but resistant to SPONV infection. In contrast, rhesus macaques () supported productive infection with both ZIKV and SPONV and developed robust neutralizing antibody responses. Crossover serial challenge in rhesus macaques revealed that SPONV immunity did not protect against ZIKV infection, whereas ZIKV immunity was fully protective against SPONV infection. These findings establish a viable model for future investigation into SPONV pathogenesis and suggest that the risk of SPONV emergence is low in areas with high ZIKV seroprevalence due to one-way cross-protection between ZIKV and SPONV.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10313173 | PMC |
| http://dx.doi.org/10.1126/sciadv.adg3444 | DOI Listing |
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