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Variations in kinase and effector signaling logic in a bacterial two component signaling network.
bioRxiv
November 2024
Structural Biology Initiative, CUNY Advanced Science Research Center, New York, NY 10031.
The general stress response (GSR) protects bacteria from a wide range of stressors. In , GSR activation is coordinated by HWE/HisKA2 family histidine kinases (HKs), which can exhibit non-canonical structure and function. For example, while most light-oxygen-voltage sensor-containing HKs are light activated dimers, the RT-HK has inverted "dark on, light off" signaling logic with a tunable monomer/dimer equilibrium.
View Article and Find Full Text PDFThe Gunslinger's sign in atypical parkinsonism.
J Neurol Sci
November 2024
Department of Neurology, Santa Maria University Hospital, Terni, Italy.
Fine Needle Aspiration Cytology of Pancreatoblastoma in Adult/Adolescent Patients, One With Histology Mimicking NUT Carcinoma.
Diagn Cytopathol
February 2025
Department of Pathology and Laboratory Medicine, Henry Ford Hospital, Detroit, Michigan, USA.
Article Synopsis
- Pancreatoblastoma is a rare malignant tumor primarily affecting children, but can occasionally appear in adults, complicating cytologic diagnosis because of its mixed cellular structure and the need for squamoid nests.
- Two patients were studied: one was a 38-year-old male with pancreatic and liver lesions featuring a biphasic malignancy, while the second was a 24-year-old female with a past diagnosis related to Gardner's syndrome, showing atypical cells in lymph nodes.
- The study also included a literature review discussing differential diagnosis and necessary tests for accurate identification of pancreatoblastoma.
DSD-related attitudes and beliefs held by pediatric endocrinologists and urologists: Insights from the North American disorders/differences of sex development (DSD) clinician survey.
J Pediatr Urol
December 2024
Susan B. Meister Child Health Evaluation and Research (CHEAR) Center, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Division of Pediatric Psychology, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address:
Background: Disorders/Differences of Sex Development (DSD) encompass congenital conditions with atypical development of chromosomal, gonadal, or anatomical sex. Due to the rarity and complexity of these conditions, strong evidence for clinical practices is scarce, leading to controversies in management.
Objective: This study, part of a broader project, examines changes over time in the attitudes and beliefs of DSD healthcare providers, focusing on factors contributing to patients' life satisfaction and the influence of medical specialty, gender, and age.
Leukemia cutis as a prominent clinical sign in a dog with acute myeloid leukemia.
Vet Clin Pathol
December 2024
Department of Clinical Sciences and Services, Royal Veterinary College, Hatfield, Hertfordshire, UK.
Article Synopsis
- An eight-year-old neutered crossbreed dog presented with severe skin lesions and signs of systemic illness, leading to a thorough hematologic assessment.
- The tests revealed nonregenerative anemia, thrombocytopenia, and a high population of neoplastic mononuclear cells, ultimately diagnosing the dog with acute myeloid leukemia (AML).
- Despite findings of AML affecting multiple organs, the owner opted for euthanasia, marking this case as the first documented instance of ulcerative skin lesions linked to AML in a dog.
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