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Altered intestinal microbiota in children with bronchiolitis. | LitMetric

AI Article Synopsis

  • The study aimed to explore the link between changes in gut microbiota and bronchiolitis in children, involving 57 affected kids and 36 healthy controls for comparison.
  • Results showed that children with bronchiolitis had lower diversity of gut bacteria and specific imbalances in bacterial populations, including decreased short-chain fatty acid (SCFA)-producing bacteria.
  • The findings suggest that altered gut microbiota and changes in certain metabolites may contribute to bronchiolitis in children, with potential for using specific bacterial metabolites as predictors or treatments for the condition.

Article Abstract

Objective: To investigate the correlation between the alteration of intestinal microbiota and disease in children with bronchiolitis.

Methods: Fifty seven children diagnosed with bronchiolitis from January 2020 to January 2022 in our pediatric department were included as the case group, and another 36 normal children were included as the control group. Stool and blood were collected from both groups for high-throughput sequencing, untargeted metabolite detection and ELISA. A mouse model of RSV infection was established to validate the results of clinical case detection.

Results: Body weight, passive smoking, and a host of other factors were possible as acute bronchiolitis influencing factors in the onset of acute bronchiolitis. The alpha diversity Shannon, Simpson and Pielou's evenness indices were significantly lower in children with acute bronchiolitis than in healthy children with gated levels of Firmicutes, Bacteroidetes and genus levels of Clostridium and other short chain fatty acid-producing bacteria. The relative abundance of short-chain fatty acid (SCFAs)-producing bacteria decreased and the abundance of genus-level sphingolipid-producing bacteria Sphingomonas increased; the progression of acute bronchiolitis is likely to be associated with the abundance of Clostridium and Sphingomonas and higher fecal amino acid concentrations, including FF-MAS, L-aspartic acid, thioinosinic acid, picolinic acid; supplementation with significantly alleviated RSV infection-induced lung inflammation.

Conclusion: The progression of bronchiolitis may be associated with altered intestinal microbiota, decreased SCFAs and elevated sphingolipids metabolism in children. Some fecal bacteria and metabolites may predict the onset of bronchiolitis, and oral administration of may alleviate RSV infection-induced pulmonary inflammation.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10306280PMC
http://dx.doi.org/10.3389/fmicb.2023.1197092DOI Listing

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