AI Article Synopsis
- Research on families shows that siblings with autism share more of their father's genetic material than expected, suggesting genetics play a significant role in autism risk.
- The statistical significance for paternal sharing is strong (p = 0.0014), while maternal sharing is less significant (p = 0.31), challenging some existing beliefs about parental influence on autism.
- The findings imply that any comprehensive genetic model of autism must account for these patterns of parental genome sharing, which could also apply to other complex disorders.
Article Abstract
Studying thousands of families, we find siblings concordant for autism share more of their parental genomes than expected by chance, and discordant siblings share less, consistent with a role of transmission in autism incidence. The excess sharing of the father is highly significant (p value of 0.0014), with less significance for the mother (p value of 0.31). To compare parental sharing, we adjust for differences in meiotic recombination to obtain a p value of 0.15 that they are shared equally. These observations are contrary to certain models in which the mother carries a greater load than the father. Nevertheless, we present models in which greater sharing of the father is observed even though the mother carries a greater load. More generally, our observations of sharing establish quantitative constraints that any complete genetic model of autism must satisfy, and our methods may be applicable to other complex disorders.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10300587 | PMC |
| http://dx.doi.org/10.1016/j.xgen.2023.100319 | DOI Listing |
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