Background: () is an important cause of nosocomial infections, and contributes to high morbidity and mortality, especially in intensive care units. is considered a 'critical' category bacterial pathogen by the World Health Organization to encourage an urgent need for research and development of new antibiotics against its infections.
Aim: To investigate the effectiveness of baicalin combined with tobramycin therapy as a potential treatment method for carbapenem-resistant (CRPA) infections.
Methods: Polymerase chain reaction (PCR) and RT-PCR were used to detect the expression levels of drug-resistant genes (including , and ) and biofilm-related genes (including , and ) in CRPA that confer resistance to tobramycin, baicalin and tobramycin combined with baicalin (0, 1/8, 1/4, 1/2 and 1MIC).
Results: There was a correlation between biofilm formation and the expression of biofilm-related genes. In addition, , , , , and that confer biofilm production under different concentrations in CRPA were significantly correlated. The synergistic effect of baicalin combined with tobramycin was a significant down-regulation of , , , and .
Conclusion: Baicalin combined with tobramycin therapy can be an effective treatment method for patients with CRPA infection.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303599 | PMC |
| http://dx.doi.org/10.12998/wjcc.v11.i17.4026 | DOI Listing |
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