Background: eradication rates achieved with clarithromycin-based triple therapies are declining due to antibiotic resistance, but data regarding temporal changes in efficacy with these eradication therapies are scarce.
Objective: To evaluate the efficacy of clarithromycin-based triple eradication regimens over time.
Design: A comprehensive literature review and time-trend analysis.
Data Sources And Methods: Bibliographies of recently published systematic literature reviews were searched and supplemented with a targeted literature review conducted using Medline and Embase databases and ProQuest from conception to May 2021. Studies reporting eradication rates of clarithromycin-based triple therapies were included and temporal trends were estimated using a random-effects model.
Results: Eradication rates for triple therapies containing proton pump inhibitors (PPIs), clarithromycin, and amoxicillin showed a significant decline over the past 23 years ( = 0.0315). However, this decline was not significant when eradication rates achieved with vonoprazan-based triple therapy were included ( = 0.3910).
Conclusion: Vonoprazan-based triple therapy partially mitigated the decline in eradication rates seen with PPI-based triple therapy, likely due to more powerful acid suppression of vonoprazan.
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| http://dx.doi.org/10.1177/17562848231167284 | DOI Listing |
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