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http://dx.doi.org/10.1159/000524269 | DOI Listing |
GE Port J Gastroenterol
June 2023
Institute of Pathology Saarbrücken-Rastpfuhl, Saarbrücken, Germany.
Pediatr Res
June 2019
Department of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, Naples, Italy.
Background: Toxin A (TcdA), toxin B (TcdB), and binary toxin (CDT) produced by Clostridium difficile (CD) are thought to play a key role in inducing diarrhea. The aim of this study was to investigate the individual and combined roles of CD toxins in inducing enterotoxic and cytotoxic effect.
Methods: Ion secretion and epithelial damage were evaluated in the Ussing chambers as measure of enterotoxic or cytotoxic effect, respectively, in human-derived intestinal cells.
Comp Biochem Physiol C Toxicol Pharmacol
April 2019
I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, 194223 Saint-Petersburg, Russia. Electronic address:
Previously we showed that arginine-vasotocin (AVT)-stimulated osmotic water permeability (OWP) of the frog urinary bladder was decreased if the mucosal side of the bladder has been naturally colonized by Gram-negative bacteria, or if bacterial lipopolysaccharide (LPS) was introduced into the lumen of the isolated bladder (J. Exp. Zool.
View Article and Find Full Text PDFComp Biochem Physiol A Mol Integr Physiol
January 2012
Department of Biological Sciences, University of Manitoba, Winnipeg, MB, Canada.
The present study has examined the role of the colon in regulating ammonia and urea nitrogen balance in two species of chondrichthyans, the ratfish, Hydrolagus colliei (a holocephalan) and the spiny dogfish, Squalus acanthias (an elasmobranch). Stripped colonic tissue from both the dogfish and ratfish was mounted in an Ussing chamber and in both species bi-directional urea flux was found to be negligible. Urea uptake by the mucosa and serosa of the isolated colonic epithelium through accumulation of (14)C-urea was determined to be 2.
View Article and Find Full Text PDFJ Nat Med
January 2011
Laboratory of Physiology, Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, 1-1 Yanagido, Gifu 501-1193, Japan.
Ginger (rhizome of Zingiber officinale Roscoe) is an herbal medicine for the treatment of gastrointestinal disorders including constipation and diarrhea. Zingerone is a likely active constituent responsible for the antidiarrheal activity of ginger. The current study was designed to characterize pharmacological actions of zingerone on colonic motility.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!