AI Article Synopsis
- F-MRI is a non-invasive imaging technique that uses new compounds with perfluoro-tert-butyl groups as labels for tracking biological activity without ionizing radiation.
- The specific compounds tested, 1,2-bis(perfluoro-tert-butoxy)ethane and 1,3-bis(perfluoro-tert-butyl)propane, are made up of 68.67% and 71.25% fluorine atoms, respectively, and showed promising imaging contrast in lab studies.
- These compounds exhibit good biological safety and can be eliminated from the body in about 30 days after administration at a low dose, making them suitable for F-MRI applications.
Article Abstract
F MRI is a unique technique for tracking and quantifying the indicator ( F-MRI label) in vivo without the use of ionizing radiation. Here we report new F-MRI labels, which are compounds with perfluoro-tert-butyl groups: 1,2-bis(perfluoro-tert-butoxy)ethane (C F H O ) and 1,3-bis(perfluoro-tert-butyl)propane (C F H ). Both substances contain 18 equivalent F atoms, constituting 68.67 % and 71.25 % of the molecule, respectively. The emulsions with F molecules were prepared and used in F MRI studies in laboratory rats in vivo. The substances demonstrated high contrast properties, good biological inertness and the ability to be rapidly eliminated from the body. We showed that at a dose of 0.34 mg/g of body weight in rats, the time for complete elimination of C F H O and C F H is ∼30 days. The results turned out to be promising for the use of the presented compounds in F MRI applications, especially since they are quite easy to synthesize.
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