Endocrine disruptors (EDs) such as bisphenol A (BPA), nonylphenol (NP), octylphenol (OP) and heavy metals in drinking water supply represent a significant threat to human health. In Nigeria, little is known about the presence of EDs in various environmental media. This study was conducted to determine the concentrations of BPA, NP and OP in groundwater samples from selected communities in Ibadan, Nigeria. Water samples were collected from 30 different sites (26 hand-dug wells, 2 boreholes and 2 spring water sources), 15 from each of Ibadan North-West (IbNW) and Ido Local Government Area (LGA). Samples were collected in triplicate from all the sampling points and analysed for BPA, NP, OP and physicochemical parameters (including heavy metals) using a standard procedure. Bisphenol A and octylphenol were not detected in any samples, while NP was detected in spring water and the concentration (0.00279 mg/L) was less than the maximum allowable limit (0.015 mg/L). All (100.0%) boreholes in IbNW and 100.0% of the springs in Ido LGA showed iron concentrations that exceeded the permissible limit. There is a need for public awareness on the health risk of EDs in drinking water supply and appropriate preventive measures to be adopted.
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http://dx.doi.org/10.2166/wh.2023.306 | DOI Listing |
J Nanobiotechnology
December 2024
Key Laboratory of Emergency and Trauma of Ministry of Education, Engineering Research Center for Hainan Biological Sample Resources of Major Diseases, the Hainan Branch of National Clinical Research Center for Cancer, the First Affiliated Hospital, Hainan Medical University, Haikou, 570102, China.
Limited drug accumulation and an immunosuppressive microenvironment are the major bottlenecks in the treatment of glioblastoma multiforme (GBM). Herein, we report a copper-coordination driven brain-targeting nanoassembly (TCe6@Cu/TP5 NPs) for site-specific delivery of therapeutic agents and efficient immunotherapy by activating the cGAS-STING pathway and downregulating the expression of PD-L1. To achieve this, the mitochondria-targeting triphenylphosphorus (TPP) was linked to photosensitizer Chlorin e6 (Ce6) to form TPP-Ce6 (TCe6), which was then self-assembled with copper ions and thymopentin (TP5) to obtain TCe6@Cu/TP5 NPs.
View Article and Find Full Text PDFBMC Vet Res
December 2024
Department of Parasitology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.
Strongylus vulgaris, a devastating parasitic nematode in equids, causes life-threatening verminous aneurysms that are challenging to diagnose early. This study pioneered integrating nanotechnology into an indirect enzyme-linked immunosorbent assay (i-ELISA) system to enhance the sensitivity and specificity for detecting S. vulgaris larval antigens in equine serum samples, with PCR confirmation of the species.
View Article and Find Full Text PDFJ Egypt Natl Canc Inst
December 2024
Department of Community Medicine, Vinayaka Mission's Homoeopathic Medical College and Hospital, Vinayaka Mission's Research Foundation (DU), Salem, India.
Green synthesis techniques have drawn a lot of interest lately since they are beneficial to the environment and have potential uses in a variety of industries, including biomedicine. Because of their special physicochemical characteristics, copper nanoparticles (CuNPs) have become one of the most interesting options for use in biological applications among nanomaterials. An overview of green synthesis methods for CuNPs is given in this review, along with a discussion of their applications in cancer therapeutics.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
December 2024
Pharmacognosy Department, Faculty of Pharmacy, Misr International University, Cairo, Egypt.
Contamination of water by heavy toxic metal ions such as (e.g., Cr, Mn, Ni, Cu, Zn, As Pb, Cd, and Ag) can lead to serious environmental and human health problems because of their acute and chronic toxicity to the biological system.
View Article and Find Full Text PDFEnviron Manage
December 2024
College of Natural Resources and Environment, Northwest A&F University, Yangling, Shaanxi Province, 712100, PR China.
As biodegradable and bio-based plastics increasingly replace conventional plastics, the need for a comprehensive understanding of their ecotoxicity becomes more pressing. This review systematically presents the ecotoxicity of the microplastics (MPs) from different biodegradable plastics and bioplastics on various animals and plants. High doses of polylactic acid (PLA) MPs (10%) have been found to reduce plant nitrogen content and biomass, and affect the accumulation of heavy metals in plants.
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