In this paper, we present a study on the utilization of smart medical wearables and the user manuals of such devices. A total of 342 individuals provided input for 18 questions that address user behavior in the investigated context and the connections between various assessments and preferences. The presented work clusters individuals based on their professional relation to user manuals and analyzes the obtained results separately for these groups.
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http://dx.doi.org/10.3233/SHTI230506 | DOI Listing |
Brief Bioinform
November 2024
Institute of Statistics and Big Data, Renmin University of China, No. 59 Zhongguancun Street, 100872 Beijing, China.
The spatial transcriptomics is a rapidly evolving biological technology that simultaneously measures the gene expression profiles and the spatial locations of spots. With progressive advances, current spatial transcriptomic techniques can achieve the cellular or even the subcellular resolution, making it possible to explore the fine-grained spatial pattern of cell types within one tissue section. However, most existing cell spatial clustering methods require a correct specification of the cell type number, which is hard to determine in the practical exploratory data analysis.
View Article and Find Full Text PDFJ Chem Inf Model
January 2025
Biophysics Graduate Program, The Ohio State University, Columbus, Ohio 43210, United States.
Electronic structure calculations in enzymes converge very slowly with respect to the size of the model region that is described using quantum mechanics (QM), requiring hundreds of atoms to obtain converged results and exhibiting substantial sensitivity (at least in smaller models) to which amino acids are included in the QM region. As such, there is considerable interest in developing automated procedures to construct a QM model region based on well-defined criteria. However, testing such procedures is burdensome due to the cost of large-scale electronic structure calculations.
View Article and Find Full Text PDFNat Commun
January 2025
Genetics, Bioinformatics, and Computational Biology, Virginia Tech, Blacksburg, VA, USA.
Single-cell RNA sequencing (scRNA-seq) is widely used in plant biology and is a powerful tool for studying cell identity and differentiation. However, the scarcity of known cell-type marker genes and the divergence of marker expression patterns limit the accuracy of cell-type identification and our capacity to investigate cell-type conservation in many species. To tackle this challenge, we devise a novel computational strategy called Orthologous Marker Gene Groups (OMGs), which can identify cell types in both model and non-model plant species and allows for rapid comparison of cell types across many published single-cell maps.
View Article and Find Full Text PDFInt J Med Sci
January 2025
Department of Medicine and Medical Specialities. University of Alcala, Alcala de Henares, 28801 Madrid, Spain.
Antiepileptics and antidepressants are frequently prescribed for chronic pain, but their efficacy and potential adverse effects raise concerns, including dependency issues. Increased prescriptions, sometimes fraudulent, prompted reclassification of antiepileptics in some countries. Our aim is to comprehend opinions, perceptions, beliefs, and attitudes towards co-analgesics from online discussions on X (formerly known as Twitter), offering insights closer to reality than conventional surveys.
View Article and Find Full Text PDFEpilepsia
December 2024
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Objective: The most common medically resistant epilepsy (MRE) involves the temporal lobe (TLE), and children designated as temporal plus epilepsy (TLE+) have a five-times increased risk of postoperative surgical failure. This retrospective, blinded, cross-sectional study aimed to correlate visual and computational analyses of magnetoencephalography (MEG) virtual sensor waveforms with surgical outcome and epilepsy classification (TLE and TLE+).
Methods: Patients with MRE who underwent MEG and iEEG monitoring and had at least 1 year of postsurgical follow-up were included in this retrospective analysis.
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