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Investigations Reveals Potential Cytotoxic Activity of Fermentation Metabolites from Actinomycetes Isolated from Lonar Soda Lake Against HeLa Cancer Cell Lines.
Curr Protein Pept Sci
January 2025
Department of Pharmacognosy, SVKM's NMIMS, School of Pharmacy & Technology Management, Hyderabad, Telangana- 509 301, India.
Background: Actinomycetes, Gram-positive bacteria, are recognized for producing bioactive metabolites. Lonar Soda Lake, an alkaline ecosystem, hosts diverse actinomycetes with possible anticancer activities.
Aim: To assess the cytotoxic potential of fermentation metabolites from actinomycetes isolated from Lonar Soda Lake against HeLa cancer cells employing and methods.
Phenolic extract from olive mill wastewater sustains mitochondrial bioenergetics upon oxidative insult.
Food Chem (Oxf)
June 2025
Dept. of Biomedical and Biotechnological Sciences, University of Catania.
In the last few years, many efforts have been devoted to the recovery and valorization of olive oil by-products because of their potentially high biological value. The olive mill wastewater (OMWW), a dark-green brown colored liquid that mainly consists of fruit vegetation water, is particularly exploited in this regard for its great content in phenolic compounds with strong antioxidant properties. In our previous work, we produced different OMWW fractions enriched in hydroxytyrosol- and hydroxytyrosol/oleuropein (i.
View Article and Find Full Text PDFClinically Deployable Electro-Immunosensing Device Comprising Bioactive Glass-MWCNT for Alkaline Phosphatase Detection in Human Serum Samples.
ACS Appl Bio Mater
January 2025
School of Biochemical Engineering, Indian Institute of Technology (Banaras Hindu University), Varanasi 221005, India.
Bone is a dynamic tissue that serves several purposes in the human body, including storing calcium, forming blood cells, and protecting and supporting the body's organs. Alkaline phosphatase (ALP) is secreted into the circulation by osteoblasts, the cells responsible for making bone. It attaches to the surface of osteoblast cells or matrix vesicles.
View Article and Find Full Text PDFScientific investigation on antibacterial, antioxidant, cytotoxic effects and TLC bioautography of stem bark extracts.
J Complement Integr Med
January 2025
PKFokam Institute of Excellence, Yaoundé, Cameroon.
Objectives: Hochst, belonging to the family, is known for its ethnomedicinal values, particularly in treating various diseases in Africa. This study aimed to investigate the antibacterial, antioxidant, and cytotoxic properties of stem bark extracts, with a specific focus on assessing their bioactive potential and identifying active compounds via TLC bioautography.
Methods: The antimicrobial activity was assessed using the agar well diffusion method against selected clinical strains.
Priming human bone marrow-derived mesenchymal stromal cells with signaling modifiers boosts their functionality: Potential application in regenerative therapies.
Int J Biochem Cell Biol
January 2025
Symbiosis Centre for Stem Cell Research, Symbiosis School of Biological Sciences, Lavale, Pune, India. Electronic address:
Mesenchymal stromal cells (MSCs) isolated from tissues such as bone marrow, cord, cord blood, etc., are frequently used as feeder layers to expand hematopoietic stem/ progenitor cells (HSCs/HSPCs) in vitro. They are also co-infused with the HSCs to improve the efficacy of transplantation.
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