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Differences in Plasma BDNF Levels Between Chronic Primary Musculoskeletal Pain, Fibromyalgia Syndrome, and Asymptomatic Subjects: A Cross-Sectional Study.
Biol Res Nurs
January 2025
Cognitive Neuroscience, Pain and Rehabilitation Research Group (NECODOR), Faculty of Health Sciences, Rey Juan Carlos University, Alcorcón, Spain.
This cross-sectional study compared plasma brain-derived neurotrophic factor (BDNF) levels among chronic primary musculoskeletal pain patients, chronic widespread pain patients, and asymptomatic controls. The study included 126 participants aged 18-65, divided into three groups of 42 each. Pain intensity was assessed using a Numeric Rating Scale (NRS), and plasma BDNF levels were measured via ELISA.
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Alzheimers Dement
December 2024
Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Background: Physically inactivity is associated with increased risk of dementia including Alzheimer's disease (AD). Prior work from the Harvard Aging Brain Study (HABS) suggests that lower baseline physical activity in cognitively unimpaired individuals with elevated amyloid burden is associated with faster prospective cognitive decline. However, whether this detrimental effect on cognition in preclinical AD is mediated by accelerated tau pathology remains unclear.
View Article and Find Full Text PDFBackground: A decline in memory is a hallmark of Alzheimer's disease (AD). Experiments in rodents and post-mortem studies in humans with AD suggest that serotonin (5-HT) plays a role in memory, but the molecular and neural mechanisms mediating its effects are unknown.
Method: 100,000 individuals in UK Biobank were studied for the role of serotonin 2C receptor (5-HTR) in the regulation of memory.
Developing Topics.
Alzheimers Dement
December 2024
Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, Maastricht, Netherlands.
Background: The locus coeruleus (LC)-norepinephrine (NE) system is one of the first systems affected in Alzheimer's Disease (AD), prior to cortical involvement. LC-NE system dysregulation has also been associated with neuropsychiatric and stress-related symptoms, early non-cognitive signals of AD. This study investigates whether structural and functional LC-NE system metrics are associated with affective and stress-related reports among predominantly cognitively healthy adults, and whether these associations are exacerbated by AD fluid biomarkers of tau, neurodegeneration and astrocyte reactivity.
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Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA.
Background: Autophagy-lysosomal pathway (ALP) dysfunction emerges early in Alzheimer's disease(AD). In mouse AD models, lysosomal acidification deficits impair ALP in neurons, in some inducing massive autolysosome accumulations, intraneuronal amyloid plaque, and early neuronal death yielding an extracellular amyloid plaque. This distinctive neurodegenerative pattern (PANTHOS) emerges in early-stage AD and is recapitulated in human late-onset AD (accompanying poster).
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