AI Article Synopsis

  • - This study analyzed the effectiveness of minimally invasive surgery (MIS) versus open surgery for treating high-risk endometrial cancer, including patients from Korea and Taiwan.
  • - After comparing outcomes in a matched sample of 284 patients, results showed no significant difference in disease-free or overall survival rates between the two surgical approaches.
  • - The study concluded that MIS is just as effective as open surgery in maintaining survival rates for endometrial cancer patients at high risk of recurrence.

Article Abstract

Background: This study compared oncologic outcomes between minimally invasive surgery (MIS) and open surgery for the treatment of endometrial cancer with a high risk of recurrence.

Methods: This study included patients with endometrial cancer who underwent primary surgery at two tertiary centers in Korea and Taiwan. Low-grade advanced-stage endometrial cancer (endometrioid grade 1 or 2) or endometrial cancer with aggressive histology (endometrioid grade 3 or non-endometrioid) at any stage was considered to have a high risk of recurrence. We conducted 1:1 propensity score matching between the MIS and open surgery groups to adjust for the baseline characteristics.

Results: Of the total of 582 patients, 284 patients were included in analysis after matching. Compared with open surgery, MIS did not show a difference in disease-free survival [hazard ratio (HR) 1.09; 95% confidence interval (CI) 0.67-1.77, P = 0.717] or overall survival (HR 0.67; 95% CI 0.36-1.24, P = 0.198). In the multivariate analysis, non-endometrioid histology, tumor size, tumor cytology, depth of invasion, and lymphovascular space invasion were risk factors for recurrence. There was no association between the surgical approach and either recurrence or mortality in the subgroup analysis according to stage and histology.

Conclusions: MIS did not compromise survival outcomes for patients with endometrial cancer with a high risk of recurrence when compared with open surgery.

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Source
http://dx.doi.org/10.1245/s10434-023-13695-xDOI Listing

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