When preservation of the nipple-areolar complex (NAC) is not possible in oncologic breast surgery, the traditional approaches are either a horizontal incision centered on the NAC resulting in visible scars and breast distortion, or a round block with risk of healing difficulties. To address these concerns, the authors propose a star approach technique for skin sparing mastectomies and lumpectomies of central breast tumors. During the oncologic surgery, the NAC is removed with four cutaneous extensions, which can be closed as a cross-shaped scar. The scarring is similar in size to the original NAC diameter and can easily be covered by the NAC reconstruction. This technique offers good exposure during surgery, a good aesthetic result with limited scarring, no breast deformity, correction of breast sagging, and high-quality healing.
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http://dx.doi.org/10.1016/j.anplas.2023.06.003 | DOI Listing |
STAR Protoc
January 2025
School of Life Sciences, Lanzhou University, Lanzhou 730000, Gansu, P.R. China; Key Laboratory of Cell Activities and Stress Adaptations, Ministry of Education, Lanzhou University, Lanzhou 730000, Gansu, P.R. China. Electronic address:
The detailed chromatin assembly processes for many epigenetic regulatory complexes are largely unknown. Here, we present a protocol utilizing heterochromatin-targeting module (HTM) module-mediated chromatin tethering followed by microscopy-based visualization to detect the recruitment priority between two components in Polycomb repressive complex 1 (PRC1). Moreover, we detail procedures for detecting the resultant histone-modifying activities of PRC1 using immunofluorescence (IF) analyses.
View Article and Find Full Text PDFTransl Psychiatry
January 2025
Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy.
Predicting disease trajectories in patients with major depressive disorder (MDD) can allow designing personalized therapeutic strategies. In this study, we aimed to show that measuring patients' plasticity - that is the susceptibility to modify the mental state - identifies at baseline who will recover, anticipating the time to transition to wellbeing. We conducted a secondary analysis in two randomized clinical trials, STAR*D and CO-MED.
View Article and Find Full Text PDFImmunology
January 2025
Singapore Immunology Network (SIgN), A*STAR, Singapore, Singapore.
Cancer is one of the leading causes of death worldwide. In recent years, immune checkpoint inhibitor therapies, in addition to standard immuno- or chemotherapy and surgical approaches, have massively improved the outcome for cancer patients. However, these therapies have their limitations and improved strategies, including access to reliable cancer vaccines, are needed.
View Article and Find Full Text PDFJ Am Chem Soc
January 2025
Innovative Centre for Flexible Devices (iFLEX), Max Planck-NTU Joint Laboratory for Artificial Senses, School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore.
Current lithium batteries experience significant performance degradation under extreme temperature conditions, both high and low. Traditional wide-temperature electrolyte designs typically addressed these challenges by manipulating the solvation sheath and selecting solvents with extreme melting/boiling points. However, these solvent-mediated solutions, while effective at one temperature extreme, invariably fail at the opposite end due to the inherent difficulties in maintaining solvent stability across wide temperatures.
View Article and Find Full Text PDFSmall Methods
January 2025
School of Chemistry and Materials, Department of Chemistry, Laboratory of Advanced Materials, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, P. R. China.
The unique adhesion capabilities of soft-bodied creatures such as leeches and octopuses have provided considerable inspiration for the development of artificial adhesive materials. However, previous studies have either focused on the design of sucker structures or concentrated on the synthesis of adhesive materials, with the combination of these two aspects not yet having been deeply investigated. In this study, inspired from leech's unique adsorption ability, a biomimetic approach is proposed that combined artificial sucker and mucus, to achieve remarkable adhesion stability on rough surfaces using 5 cm diameter silicone suction cups.
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